Sayed Shimaa M A, Siems Karsten, Schmitz-Linneweber Christian, Luyten Walter, Saul Nadine
Molecular Genetics Group, Institute of Biology, Faculty of Life Sciences, Humboldt University of Berlin, Berlin, Germany.
Botany and Microbiology Department, Faculty of Science, New Valley University, El-Kharga, Egypt.
Front Pharmacol. 2021 Feb 2;12:604435. doi: 10.3389/fphar.2021.604435. eCollection 2021.
To uncover potential anti-aging capacities of Traditional Chinese Medicine (TCM), the nematode was used to investigate the effects of and extracts, selected by screening seven TCM extracts, on different healthspan parameters. Nematodes exposed to and extracts, starting at the young adult stage, exhibited prolonged lifespan and increased survival after heat stress as well as upon exposure to the pathogenic bacterium , whereby the survival benefits were monitored after stress initiation at different adult stages. However, only had the ability to enhance physical fitness: the swimming behavior and the pharyngeal pumping rate of were improved at day 7 and especially at day 12 of adulthood. Finally, monitoring the red fluorescence of aged worms revealed that only extracts caused suppression of intestinal autofluorescence, a known marker of aging. The results underline the different modes of action of the tested plants extracts. improved specifically the physiological fitness by increasing the survival probability of after stress, while seems to be an overall healthspan enhancer, reflected in the suppressed autofluorescence, with beneficial effects on physical as well as physiological fitness. The effects may be hormetic: this is supported by increased gene expression of and by trend, also of .
为了揭示传统中药（TCM）潜在的抗衰老能力，利用线虫研究了通过筛选七种中药提取物而选出的[提取物名称1]和[提取物名称2]提取物对不同健康寿命参数的影响。从成虫早期开始接触[提取物名称1]和[提取物名称2]提取物的线虫，其寿命延长，热应激后以及接触致病菌[细菌名称]后的存活率增加，在不同成虫阶段开始应激后监测存活益处。然而，只有[提取物名称1]有增强体能的能力：在成年期第7天，尤其是第12天，[提取物名称1]处理的线虫的游泳行为和咽泵浦率得到改善。最后，监测老龄线虫的红色荧光发现，只有[提取物名称2]提取物能抑制肠道自发荧光，这是一种已知的衰老标志物。结果强调了受试植物提取物的不同作用模式。[提取物名称1]通过增加应激后[线虫名称]的存活概率特异性地改善了生理适应性，而[提取物名称2]似乎是一种整体健康寿命增强剂，表现为自发荧光受到抑制，对体能和生理适应性均有有益影响。[提取物名称2]的作用可能是 hormetic 效应：这得到了[基因名称1]基因表达增加的支持，并且在趋势上，[基因名称2]的表达也增加。
