Suzuki K, Akagi T, Toyoda O, Mikajima T, Inoue O, Yokochi K, Kato H
Department of Pediatrics and Child Health, Kurume University School of Medicine.
J Cardiol. 1988 Jun;18(2):425-33.
From June 1984 to March 1987, percutaneous balloon valvuloplasty (PBV) was performed for 22 patients with congenital pulmonary valvular stenosis. It was successful for 20 patients, and there were significant decreases of transvalvular pressure gradients; 72 +/- 30 mmHg before PBV, and 30 +/- 12 mmHg immediately after PBV (p less than 0.001). In a follow-up study, pulsed Doppler echocardiography and cardiac catheterization were used to examine changes in long-term hemodynamic findings after PBV. One year follow-up evaluation was performed for 14 patients, and two year follow-ups for seven patients. One year after PBV the transvalvular pressure gradients were evaluated during cardiac catheterization in 11 patients, and using pulsed Doppler echocardiography in the remaining three patients. The gradients of the seven patients at two year intervals after PBV were evaluated using pulsed Doppler echocardiography. The pressure gradients of two patients improved further one year later due to the anatomical degradation in the right ventricular outflow tracts. For seven patients, two year follow-up evaluations were performed, and the transvalvular pressure gradient reduced from 84 +/- 23 to 33 +/- 15 mmHg (p less than 0.001) immediately afterwards; to 27 +/- 22 mmHg (p less than 0.01) one year later; and further to 12 +/- 5 mmHg (p less than 0.001) two years after PBV. Second PBV was performed for three patients in whom a residual gradient was recognized, with the good results. On auscultation, a pulmonary regurgitant murmur was recognized in 28% of 18 patients immediately after PBV, but 80% of this resolved one year later. Two patients had pulmonary regurgitation with pulmonary valvular stenosis before PBV.(ABSTRACT TRUNCATED AT 250 WORDS)
1984年6月至1987年3月,对22例先天性肺动脉瓣狭窄患者实施了经皮球囊瓣膜成形术(PBV)。20例患者手术成功,跨瓣压差显著降低;PBV术前为72±30 mmHg,术后即刻为30±12 mmHg(p<0.001)。在一项随访研究中,采用脉冲多普勒超声心动图和心导管检查来检测PBV术后长期血流动力学变化。对14例患者进行了1年随访评估,7例患者进行了2年随访。PBV术后1年,11例患者在心导管检查时评估了跨瓣压差,其余3例患者采用脉冲多普勒超声心动图评估。PBV术后2年,对7例患者采用脉冲多普勒超声心动图评估了跨瓣压差。2例患者由于右心室流出道解剖结构退化,1年后压差进一步改善。对7例患者进行了2年随访评估,术后即刻跨瓣压差从84±23 mmHg降至33±15 mmHg(p<0.001);1年后降至27±22 mmHg(p<0.01);PBV术后2年进一步降至12±5 mmHg(p<0.001)。对3例存在残余压差的患者实施了二次PBV,效果良好。听诊发现,18例患者中有28%在PBV术后即刻出现肺动脉反流杂音,但其中80%在1年后消失。2例患者在PBV术前存在肺动脉反流合并肺动脉瓣狭窄。(摘要截选至250词)