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1
Vitamin D Supplementation in Influenza and COVID-19 Infections Comment on: "Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths" 2020, (4), 988.维生素 D 补充剂在流感和 COVID-19 感染中的作用 评论：“维生素 D 补充剂可降低流感和 COVID-19 感染及死亡风险的证据”，2020 年，（4），988.
Nutrients. 2020 Jun 1;12(6):1626. doi: 10.3390/nu12061626.
2
Reply: "Vitamin D Supplementation in Influenza and COVID-19 Infections. Comment on: Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths 2020, (4), 988".回复：“维生素 D 补充剂在流感和 COVID-19 感染中的作用。评论：维生素 D 补充剂可降低流感和 COVID-19 感染及死亡风险的证据 2020，（4），988”。
Nutrients. 2020 Jun 1;12(6):1620. doi: 10.3390/nu12061620.
3
Vitamin D Insufficiency May Account for Almost Nine of Ten COVID-19 Deaths: Time to Act. Comment on: "Vitamin D Deficiency and Outcome of COVID-19 Patients". 2020, , 2757.维生素 D 不足可能导致近十分之九的 COVID-19 死亡：是采取行动的时候了。评论：“维生素 D 缺乏与 COVID-19 患者结局”。2020 年，2757 年。
Nutrients. 2020 Nov 27;12(12):3642. doi: 10.3390/nu12123642.
4
Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.证据表明，维生素 D 补充剂可能降低流感和 COVID-19 感染及死亡风险。
Nutrients. 2020 Apr 2;12(4):988. doi: 10.3390/nu12040988.
5
Reply to: "Vitamin D Insufficiency May Account for Almost Nine of Ten COVID-19 Deaths: Time to Act. Comment on: Vitamin D Deficiency and Outcome of COVID-19 Patients. 2020, , 2757".回复：“维生素 D 不足可能导致近十分之九的 COVID-19 死亡：是采取行动的时候了。评论：维生素 D 缺乏和 COVID-19 患者的结果。2020 年，，2757”。
Nutrients. 2020 Nov 27;12(12):3643. doi: 10.3390/nu12123643.
6
Vitamin D deficiency and the COVID-19 pandemic.维生素 D 缺乏与 COVID-19 大流行。
J Glob Antimicrob Resist. 2020 Sep;22:133-134. doi: 10.1016/j.jgar.2020.05.006. Epub 2020 May 29.
7
Letter to the Editor: Is Vitamin D One of the Key Elements in COVID-19 Days?致编辑的信：维生素D是新冠疫情期间的关键要素之一吗？
J Nutr Health Aging. 2020;24(9):1038-1039. doi: 10.1007/s12603-020-1413-5.
8
Pernicious anaemia: switch to oral B12 supplementation to reduce risk of covid-19 transmission.恶性贫血：改用口服维生素B12补充剂以降低新冠病毒传播风险。
BMJ. 2020 Jun 17;369:m2383. doi: 10.1136/bmj.m2383.
9
25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2.25-羟维生素 D 浓度在 SARS-CoV-2 阳性 PCR 患者中较低。
Nutrients. 2020 May 9;12(5):1359. doi: 10.3390/nu12051359.
10
Vitamin D status as a predictor of Covid-19 risk in Black, Asian and other ethnic minority groups in the UK.维生素D状态作为英国黑人、亚洲人和其他少数族裔群体感染新冠病毒风险的预测指标
Diabetes Metab Res Rev. 2020 Nov;36(8):e3375. doi: 10.1002/dmrr.3375. Epub 2020 Jul 31.

引用本文的文献

1
Vitamin D: A key player in COVID-19 immunity and lessons from the pandemic to combat immune-evasive variants.维生素 D：在 COVID-19 免疫中的关键角色，以及从大流行中吸取的对抗免疫逃避变异体的经验教训。
Inflammopharmacology. 2024 Dec;32(6):3631-3652. doi: 10.1007/s10787-024-01578-w. Epub 2024 Oct 16.
2
Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID-19: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.维生素 D 补充对 COVID-19 成年患者临床结局的影响：一项 GRADE 评估的随机对照试验系统评价和荟萃分析。
Pharmacol Res Perspect. 2024 Oct;12(5):e70013. doi: 10.1002/prp2.70013.
3
Physiological Basis for Using Vitamin D to Improve Health.使用维生素D改善健康的生理基础。
Biomedicines. 2023 May 26;11(6):1542. doi: 10.3390/biomedicines11061542.
4
The published trend of studies on COVID-19 and dietary supplements: Bibliometric analysis.发表的关于 COVID-19 和膳食补充剂的研究趋势：文献计量分析。
Front Immunol. 2022 Nov 16;13:1065724. doi: 10.3389/fimmu.2022.1065724. eCollection 2022.
5
Conflict of Interests in the Scientific Production on Vitamin D and COVID-19: A Scoping Review.维生素 D 与 COVID-19 科研成果中的利益冲突：范围综述。
Front Public Health. 2022 Jul 11;10:821740. doi: 10.3389/fpubh.2022.821740. eCollection 2022.
6
Malnutrition and Dietary Habits Alter the Immune System Which May Consequently Influence SARS-CoV-2 Virulence: A Review.营养不良和饮食习惯改变免疫系统，从而可能影响 SARS-CoV-2 的毒力：综述。
Int J Mol Sci. 2022 Feb 28;23(5):2654. doi: 10.3390/ijms23052654.
7
A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19.关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）分子结构的全面综述：对对抗COVID-19的天然产物的见解。
Pharmaceutics. 2021 Oct 21;13(11):1759. doi: 10.3390/pharmaceutics13111759.
8
Consumption of Phenolic-Rich Food and Dietary Supplements as a Key Tool in SARS-CoV-19 Infection.食用富含酚类的食物和膳食补充剂作为新冠病毒感染的关键手段。 （注：原文中SARS-CoV-19表述有误，实际指新冠病毒，这里按正确内容翻译）
Foods. 2021 Sep 3;10(9):2084. doi: 10.3390/foods10092084.
9
From the environment to the cells: An overview on pivotal factors which affect spreading and infection in COVID-19 pandemic.从环境到细胞：影响 COVID-19 大流行中传播和感染的关键因素概述。
Environ Res. 2021 Oct;201:111555. doi: 10.1016/j.envres.2021.111555. Epub 2021 Jun 28.
10
COVID-19: Role of Nutrition and Supplementation.新型冠状病毒肺炎：营养与补充的作用。
Nutrients. 2021 Mar 17;13(3):976. doi: 10.3390/nu13030976.

本文引用的文献

1
Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.证据表明，维生素 D 补充剂可能降低流感和 COVID-19 感染及死亡风险。
Nutrients. 2020 Apr 2;12(4):988. doi: 10.3390/nu12040988.
2
Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial.高剂量维生素 D 补充对体积骨密度和骨强度的影响：一项随机临床试验。
JAMA. 2019 Aug 27;322(8):736-745. doi: 10.1001/jama.2019.11889.
3
Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: results from a randomized controlled trial.每月高剂量维生素 D 补充剂不会增加肾结石风险或血清钙：一项随机对照试验的结果。
Am J Clin Nutr. 2019 Jun 1;109(6):1578-1587. doi: 10.1093/ajcn/nqy378.
4
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.补充维生素D预防急性呼吸道感染：个体参与者数据的系统评价和荟萃分析
BMJ. 2017 Feb 15;356:i6583. doi: 10.1136/bmj.i6583.
5
Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.补充维生素D3对健康个体呼吸道感染的影响：一项随机对照试验的系统评价和荟萃分析
PLoS One. 2016 Sep 15;11(9):e0162996. doi: 10.1371/journal.pone.0162996. eCollection 2016.

维生素 D 补充剂在流感和 COVID-19 感染中的作用 评论：“维生素 D 补充剂可降低流感和 COVID-19 感染及死亡风险的证据”，2020 年，（4），988.

Vitamin D Supplementation in Influenza and COVID-19 Infections Comment on: "Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths" 2020, (4), 988.

机构信息

School of Postgraduate Studies, International Medical University, Kuala Lumpur 57000, Malaysia.

School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK.

出版信息

Nutrients. 2020 Jun 1;12(6):1626. doi: 10.3390/nu12061626.

DOI:10.3390/nu12061626
PMID:32492809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7352999/
Abstract

There is an ongoing debate on the use of vitamin D supplementation in reducing the risk of influenza and COVID-19 infections and deaths. A recently published article highlights a relationship between vitamin D supplementation and reduced risk of COVID-19 and influenza. This comment aims to discuss the evidence on the use of Vitamin D in people who are at risk of developing COVID-19, focusing on safety issues of the Vitamin D supplementation.

摘要

目前，关于使用维生素 D 补充剂来降低流感和 COVID-19 感染及死亡风险，一直存在争议。最近发表的一篇文章强调了维生素 D 补充剂与降低 COVID-19 和流感风险之间的关系。本文旨在讨论维生素 D 在有 COVID-19 发病风险的人群中的应用证据，重点关注维生素 D 补充剂的安全性问题。