MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
Obstetrics Department, International peace maternity and child health hospital of China, Shanghai Jiao Tong University School of Medicine, 910 Hengshan Road, Shanghai, 200030, China.
Environ Health. 2020 Jun 3;19(1):60. doi: 10.1186/s12940-020-00616-8.
Preterm birth (PTB, < 37 completed weeks' gestation) is one of the global public health concerns. Epidemiologic evidence on the potential impact of perfluoroalkyl substances (PFAS) on PTB is still limited and inconsistent. We aimed to investigate the associations between prenatal PFAS exposure and PTB among singleton live births.
We studied 2849 mother-infant pairs in the Shanghai Birth Cohort (SBC) from 2013 to 2016. Ten PFAS in maternal plasma in early pregnancy (gestational age, median (interquartile range): 15 (13-16) weeks) were measured. Primary outcomes were duration of gestation, PTB, spontaneous PTB and clinically indicated PTB. A linear regression model was used to assess the associations between ln-transformed PFAS and duration of gestation (in weeks). Logistic regression models were applied to estimate the relative risks of these outcomes.
The incidence of overall PTB was 4.8% (95% confidence limit: 4.0-5.6%, n = 136) in this study population. In the linear regression analyses, PFAS were not associated with the duration of gestation after controlling for potential confounders. In the multiple logistic models, no significant associations were observed between PFAS and overall PTB, spontaneous or indicated PTB.
In this prospective cohort study, we did not observe significant associations between maternal plasma PFAS concentrations in early pregnancy and gestational length, overall PTB, spontaneous or indicated PTB.
早产（PTB，<37 周妊娠）是全球公共卫生关注的问题之一。有关全氟烷基物质（PFAS）对 PTB 潜在影响的流行病学证据仍然有限且不一致。我们旨在研究产前 PFAS 暴露与单胎活产儿 PTB 之间的关联。
我们研究了 2013 年至 2016 年期间上海出生队列（SBC）中的 2849 对母婴对。在妊娠早期（妊娠年龄，中位数（四分位距）：15（13-16）周）测量了母亲血浆中的十种 PFAS。主要结局是妊娠持续时间、PTB、自发性 PTB 和临床指示性 PTB。线性回归模型用于评估 ln 转换的 PFAS 与妊娠持续时间（周）之间的关联。应用逻辑回归模型估计这些结局的相对风险。
在该研究人群中，总体 PTB 的发生率为 4.8%（95%置信区间：4.0-5.6%，n=136）。在控制了潜在混杂因素后，PFAS 与妊娠持续时间无关联。在多因素逻辑回归模型中，PFAS 与总 PTB、自发性或指示性 PTB 之间未观察到显著关联。
在这项前瞻性队列研究中，我们没有观察到妊娠早期母亲血浆 PFAS 浓度与胎龄、总 PTB、自发性或指示性 PTB 之间存在显著关联。
