Wang Jian, Du Bowen, Wu Yujian, Li Zhuoyan, Wang Hualin, Niu Yiwei, Ye Yujiao, Chen Qian, Wang Qianchuo, Wu Yurong, Chen Sun, Zhang Xi, Zhang Jun, Sun Kun
Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Environ Int. 2023 Mar;173:107748. doi: 10.1016/j.envint.2023.107748. Epub 2023 Jan 12.
High maternal plasma perfluoroalkyl substances (PFAS) concentrations has been associated with adverse birth outcomes, but data on early childhood cardiovascular health is limited. This study aimed to assess the potential association between maternal plasma PFAS concentrations during early pregnancy and cardiovascular development in offspring.
Cardiovascular development was assessed through blood pressure measurement, echocardiography and carotid ultrasound examinations among 957 children from the Shanghai Birth Cohort aged at 4 years old. Maternal plasma concentrations of PFAS were measured at mean gestational age of 14.4 (SD:1.8) weeks. The joint associations between PFAS mixture concentrations and cardiovascular parameters were analyzed using a Bayesian kernel machine regression (BKMR). The potential association of individual PFAS chemicals concentrations was explored using multiple linear regression.
In BKMR analyses, carotid intima media thickness (cIMT), interventricular septum thickness in diastole and systole, posterior wall thicknesses in diastole and systole, and relative wall thickness were significantly lower when all log10-transformed PFAS were fixed at 75th percentile in comparison to at their 50th percentile[Estimated overall Risk:-0.31 (95%CI: -0.42, -0.20), -0.09 (95%CI: -0.11, -0.07), -0.21 (95%CI: -0.26, -0.16), -0.09 (95%CI: -0.11, -0.07), -0.07 (95%CI: -0.10, -0.04) and -0.005 (95%CI: -0.006, -0.004)].Furthermore, maternal plasma concentrations of individual short-chain PFAS was associated with a decrease in left ventricular wall thickness, intraventricular septum thickness and enlarged chamber volume, and long-chain with a decrease in cIMT.
Our findings suggest that maternal plasma PFAS concentrations during early pregnancy was adversely associated with cardiovascular development in offspring, including thinner cardiac wall thickness and cIMT.
孕妇血浆中全氟烷基物质（PFAS）浓度升高与不良出生结局有关，但关于儿童早期心血管健康的数据有限。本研究旨在评估孕早期孕妇血浆PFAS浓度与后代心血管发育之间的潜在关联。
对来自上海出生队列的957名4岁儿童进行血压测量、超声心动图和颈动脉超声检查，以评估心血管发育情况。在平均孕周14.4（标准差：1.8）周时测量孕妇血浆中PFAS的浓度。使用贝叶斯核机器回归（BKMR）分析PFAS混合物浓度与心血管参数之间的联合关联。使用多元线性回归探索个体PFAS化学物质浓度的潜在关联。
在BKMR分析中，与第50百分位数相比，当所有经log10转换的PFAS固定在第75百分位数时，颈动脉内膜中层厚度（cIMT）、舒张期和收缩期室间隔厚度、舒张期和收缩期后壁厚度以及相对壁厚度均显著降低[估计总体风险：-0.31（95%置信区间：-0.42，-0.20），-0.09（95%置信区间：-0.11，-0.07），-0.21（95%置信区间：-0.26，-0.16），-0.09（95%置信区间：-0.11，-0.07），-0.07（95%置信区间：-0.10，-0.04）和-0.005（95%置信区间：-0.006，-0.004）]。此外，孕妇血浆中个体短链PFAS的浓度与左心室壁厚度、室内间隔厚度降低和腔室容积增大有关，而长链PFAS与cIMT降低有关。
我们的研究结果表明，孕早期孕妇血浆PFAS浓度与后代心血管发育存在不良关联，包括心脏壁厚度和cIMT变薄。
