Service de Psychiatrie de l'Adulte, Centre Hospitalier Universitaire de Besançon, 25030, Besançon Cedex, France.
Laboratoire de Neurosciences Intégratives et Cliniques EA481, Université de Bourgogne Franche-Comté, 19 rue Ambroise Paré, 25000, Besançon, France.
Trials. 2020 Jun 3;21(1):461. doi: 10.1186/s13063-020-04412-0.
Transcranial direct current stimulation (tDCS) is promising for improving motor and cognitive performance. Nevertheless, its mechanisms of action are unclear and need to be better characterised according to the stimulated brain area and the type of exercise performed.
METHODS/DESIGN: This is a double-blind crossover study, organised into two parts: the first is to assess the effects of tDCS on explosive performance (jump task) and the second is to assess the effects on endurance performance (cycling time trial task). Participants, who are recreationally active or athletes (parkour practitioners, cyclists), will receive two active tDCS sessions (over the left dorsolateral prefrontal cortex and right motor cortex) and one sham tDCS session (part A), or two sequences (one active and one sham) of two daily tDCS sessions over 5 days (part B). Motor and cognitive performance will be compared before and after tDCS sessions (part A), and before and after the first session, after the last session and at day 12 and day 30 of each tDCS sequence (part B).
This study investigates the acute and repeated effects of tDCS on the motor and cognitive performance of healthy subjects. It will try to evaluate if tDCS could be considered as a neuroenhancement technology according to the physical task investigated (endurance versus explosive).
ClinicalTrials.gov, NCT03937115. Registered on 3 May 2019; retrospectively registered.
经颅直流电刺激(tDCS)在改善运动和认知表现方面具有广阔的应用前景。然而,其作用机制尚不清楚,需要根据刺激的脑区和所进行的运动类型进行更好地描述。
方法/设计:这是一项双盲交叉研究,分为两部分:第一部分评估 tDCS 对爆发力(跳跃任务)的影响,第二部分评估 tDCS 对耐力表现(计时骑行任务)的影响。参与者为业余或专业运动员(跑酷运动员、自行车手),将接受两次主动 tDCS 治疗(左背外侧前额叶皮质和右运动皮质)和一次假 tDCS 治疗(A 部分),或两次为期 5 天的每日 tDCS 治疗的两种序列(主动和假 tDCS 各一次)(B 部分)。在 tDCS 治疗前后(A 部分),以及每次 tDCS 序列的第一次治疗前、最后一次治疗后、第 12 天和第 30 天进行运动和认知表现的比较(B 部分)。
本研究调查了 tDCS 对健康受试者运动和认知表现的急性和重复影响。它将尝试评估 tDCS 是否可以根据所研究的物理任务(耐力与爆发力)被视为一种神经增强技术。
ClinicalTrials.gov,NCT03937115。于 2019 年 5 月 3 日注册;回顾性注册。