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用于活性氧物种清除和缓解炎症相关疾病的超小铜基纳米颗粒。

Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases.

机构信息

Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University), 400038, Chongqing, China.

Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), 400038, Chongqing, China.

出版信息

Nat Commun. 2020 Jun 3;11(1):2788. doi: 10.1038/s41467-020-16544-7.

DOI:10.1038/s41467-020-16544-7
PMID:32493916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7270130/
Abstract

Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment is currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) with good reactive oxygen species (ROS) scavenging ability and biocompatibility is a promising way for the treatment of ROS-related inflammation. Herein we report a simple and efficient one-step development of ultrasmall CuO nanoparticles (CuO USNPs) with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability for the treatment of ROS-related diseases. CuO USNPs simultaneously possessing catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of CuO USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of CuO USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes.

摘要

氧化应激与许多急性和慢性炎症性疾病有关，但目前临床上可用的治疗方法有限。具有良好的活性氧 (ROS) 清除能力和生物相容性的酶模拟纳米材料 (纳米酶) 的开发是治疗 ROS 相关炎症的一种很有前途的方法。本文报道了一种简单高效的一步法制备具有多种酶模拟和广谱 ROS 清除能力的超小氧化铜纳米颗粒 (CuO USNPs)，用于治疗与 ROS 相关的疾病。CuO USNPs 同时具有过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶模拟酶特性，在极低剂量下对 ROS 介导的损伤具有细胞保护作用，并显著改善急性肾损伤、急性肝损伤和伤口愈合的治疗效果。同时，CuO USNPs 的超小尺寸使得纳米材料能够快速从肾脏清除，保证了生物相容性。CuO USNPs 的保护作用和良好的生物相容性将有助于 ROS 相关疾病的临床治疗，并能够开发下一代纳米酶。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/8d67ae35c932/41467_2020_16544_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/cbf9316afcd2/41467_2020_16544_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/3b32156fbbc2/41467_2020_16544_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/1756396f721e/41467_2020_16544_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/7ead8cbfef3b/41467_2020_16544_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/c930b8880595/41467_2020_16544_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/7a95c4f12569/41467_2020_16544_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/b329ac08fb0e/41467_2020_16544_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/b2102b38e88e/41467_2020_16544_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/8d67ae35c932/41467_2020_16544_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/cbf9316afcd2/41467_2020_16544_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/3b32156fbbc2/41467_2020_16544_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/1756396f721e/41467_2020_16544_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/7ead8cbfef3b/41467_2020_16544_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/c930b8880595/41467_2020_16544_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/7a95c4f12569/41467_2020_16544_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/b329ac08fb0e/41467_2020_16544_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/b2102b38e88e/41467_2020_16544_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7912/7270130/8d67ae35c932/41467_2020_16544_Fig9_HTML.jpg

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本文引用的文献

[1]
A Melanin-Based Natural Antioxidant Defense Nanosystem for Theranostic Application in Acute Kidney Injury.

Adv Funct Mater. 2019-11-28

[2]
Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease.

Theranostics. 2019-4-13

[3]
Enhanced photolysis stability of CuO grown on Cu nanowires with nanoscale twin boundaries.

Nanoscale. 2019-8-7

[4]
Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization.

Biomaterials. 2019-4-17

[5]
Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice.

Nat Commun. 2018-12-21

[6]
Chiral Molecule-mediated Porous Cu O Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson's Disease.

J Am Chem Soc. 2018-12-28

[7]
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury.

Nat Biomed Eng. 2018-11

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Nano Res. 2018-10

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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.

Nat Rev Cardiol. 2018-9

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Synthesis of graphene oxide-quaternary ammonium nanocomposite with synergistic antibacterial activity to promote infected wound healing.

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