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钼基纳米团簇作为抗氧化剂可改善小鼠急性肾损伤。

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice.

机构信息

Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.

Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, 518060, Shenzhen, China.

出版信息

Nat Commun. 2018 Dec 21;9(1):5421. doi: 10.1038/s41467-018-07890-8.

DOI:10.1038/s41467-018-07890-8
PMID:30575745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6303396/
Abstract

Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases.

摘要

急性肾损伤（AKI）是一种常见的与活性氧（ROS）相关的肾脏疾病，每年导致大量死亡，但目前临床上仅提供支持性治疗。开发具有高肾积累率的抗氧化剂对于预防 AKI 非常重要。在这里，我们报告了具有优先肾脏摄取能力的钼基多金属氧酸盐（POM）纳米簇作为新型肾脏保护纳米抗氧化剂。这些 POM 纳米簇具有易于变化的钼离子价态，具有清除有害 ROS 的能力。我们的结果表明，POM 纳米簇可以通过 Ga-EDTA 动态 PET 成像、血清检测、肾脏组织染色和肾脏生物标志物检测，有效缓解 AKI 小鼠的临床症状。POM 纳米簇对活体动物 AKI 的保护作用表明，可探索其用于治疗 AKI 患者以及其他与 ROS 相关疾病的患者。

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