Boskabadi Hassan, Heidari Elahe, Zakerihamidi Maryam
Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Midwifery, Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
Iran J Microbiol. 2020 Apr;12(2):89-97.
Neonatal meningitis is one of the most important and serious neonatal infections with a high mortality and morbidity rate. The present study aimed to investigate the causes, clinical signs, laboratory parameters and mortality rates in newborns with bacterial meningitis.
This cross-sectional study was performed on 468 neonates aged 2-28 days admitted to NICU in Ghaem Hospital Mashhad, Iran by available sampling method during 2009-2018. Meningitis was confirmed according to positive results of CSF culture and clinical feature. By using researcher-made questionnaire, neonate's individual data including cardiopulmonary resuscitation, the Apgar score of the first and fifth minutes, gestational age, birth weight, clinical symptoms and laboratory data such as ESR, WBC and positive culture of CSF were studied.
Among 468 newborn suspected to infection, lumbar Puncture (LP) was performed for 233 cases (50%). Of 233 neonates, 148 neonates (63.5%) had negative results for CSF culture and 85 cases (36.5%) had positive CSF culture. 94% of cases with meningitis were born premature. Blood culture had positive results in 80% of infants with late-onset meningitis and negative in 20%. The most common clinical findings were respiratory symptoms (94%). and were the most common microorganisms of meningitis. Gestational disorders were observed in 55.3% of newborns with meningitis. C-Reactive Protein (CRP) of neonates with meningitis was twice higher than normal cases, and leukocytes and proteins in the CSF in neonates with meningitis were higher than healthy ones. Finally, 36% of neonates with meningitis died in our study. For analyzing the relationships between variables, independent t-test was used after controlling the normality, and Chi-square was used for analyzing the relationship of variables with nominal scale.
The most common pathogens of meningitis were and . Respiratory symptoms were the most common clinical signs, and laboratory symptoms included increased CRP, increased leukocytes and proteins in CSF.
新生儿脑膜炎是最重要且严重的新生儿感染之一，死亡率和发病率很高。本研究旨在调查细菌性脑膜炎新生儿的病因、临床症状、实验室指标及死亡率。
本横断面研究于2009年至2018年期间，采用便利抽样法，对伊朗马什哈德加姆医院新生儿重症监护病房收治的468例2至28日龄新生儿进行。根据脑脊液培养阳性结果和临床特征确诊脑膜炎。通过使用研究者自制问卷，研究新生儿的个体数据，包括心肺复苏、第1分钟和第5分钟的阿氏评分、胎龄、出生体重、临床症状以及实验室数据，如血沉、白细胞计数和脑脊液培养阳性情况。
在468例疑似感染的新生儿中，233例（50%）进行了腰椎穿刺（LP）。在这233例新生儿中，148例（63.5%）脑脊液培养结果为阴性，85例（36.5%）脑脊液培养结果为阳性。94%的脑膜炎病例为早产儿。80%的晚发性脑膜炎婴儿血培养结果为阳性，20%为阴性。最常见的临床症状是呼吸道症状（94%）。[此处原文缺失两种最常见的脑膜炎微生物名称]是脑膜炎最常见的微生物。55.3%的脑膜炎新生儿存在妊娠相关疾病。脑膜炎新生儿的C反应蛋白（CRP）比正常病例高出两倍，脑膜炎新生儿脑脊液中的白细胞和蛋白质含量高于健康新生儿。最后，在我们的研究中，36%的脑膜炎新生儿死亡。为分析变量之间的关系，在控制正态性后使用独立t检验，使用卡方检验分析变量与名义尺度之间的关系。
脑膜炎最常见的病原体是[此处原文缺失两种病原体名称]。呼吸道症状是最常见的临床体征，实验室症状包括CRP升高、脑脊液中白细胞和蛋白质增加。
