Zarif Hafiz Muhammad Asif, Farid Muhammad Shahzad, Shahid Muhammad, Khan Momin Rasheed, Abid Muhammad Shoaib, Akhtar Burhan, Hashmi Kashif A, Zakria Muhammad, Khan Aamna
Cardiology, Chaudhry Pervaiz Elahi Institute of Cardiology, Multan, PAK.
Family Medicine, Tehsil Headquarter Hospital Fort Munro, Dera Ghazi Khan, PAK.
Cureus. 2020 May 1;12(5):e7913. doi: 10.7759/cureus.7913.
Introduction Our objective was to determine the severity frequency of coronary artery disease (CAD) in prediabetes patients undergoing coronary angiography (CAG) in a catheterization laboratory. Materials and methods This descriptive comparative study was conducted on patients who were planned for elective CAG in the hospital from January 2019 to November 2019. The study includes patients age ≥40 years undergoing elective CAG with or without percutaneous coronary intervention/percutaneous transluminal coronary angioplasty. There were 458 patients (381 men and 77 women) in this study that were categorized into three groups on the basis on their glycated hemoglobin (HbA1c) levels: group I (n = 143) as non-diabetes, group II (n = 110) as prediabetes, and group III (n = 205) as diabetes. The severity of CAD was determined using the Gensini score. Results A total of 458 patients were included. Of these, 44.97% had hypertension; n = 36 (25.17%), n = 48 (43.63%), and n = 122 (59.51%) in group I, group II and group III, respectively (P = .0001). A total of 214 (46.72%) had a smoking history. There was a strong family history of CAD in group II (n = 29, 26.36%) and group III (n = 43, 20.98%). Group II and group III patients had a higher extension of CAD than group I (P = .01). Group II (n = 27, 41.54) and group III (n = 65, 50.39%) had a higher frequency of deployment of two stents compared to group I. Conclusion Coronary artery atherosclerosis disease increases parallel to the HbA1c severity and smoking. The present study emphasizes prediabetes as an independent risk factor for CAD.
引言 我们的目的是确定在导管实验室接受冠状动脉造影（CAG）的糖尿病前期患者中冠状动脉疾病（CAD）的严重程度和发生率。
材料与方法 本描述性比较研究针对2019年1月至2019年11月计划在医院进行择期CAG的患者开展。该研究纳入年龄≥40岁、接受择期CAG且无论是否进行经皮冠状动脉介入治疗/经皮腔内冠状动脉成形术的患者。本研究中有458例患者（381例男性和77例女性），根据糖化血红蛋白（HbA1c）水平分为三组：I组（n = 143）为非糖尿病组，II组（n = 110）为糖尿病前期组，III组（n = 205）为糖尿病组。使用Gensini评分确定CAD的严重程度。
结果 共纳入458例患者。其中，44.97%患有高血压；I组、II组和III组分别有36例（25.17%）、48例（43.63%）和122例（59.51%）（P = .0001）。共有214例（46.72%）有吸烟史。II组（n = 29，26.36%）和III组（n = 43，20.98%）有较强的CAD家族史。II组和III组患者的CAD病变范围比I组更大（P = .01）。与I组相比，II组（n = 27，41.54%）和III组（n = 65，50.39%）植入两个支架的频率更高。
结论 冠状动脉粥样硬化疾病的发生与HbA1c严重程度和吸烟情况呈平行增加。本研究强调糖尿病前期是CAD的独立危险因素。
