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小细胞前列腺癌的误诊:经验教训

Misdiagnosis of Small Cell Prostate Cancer: Lessons Learned.

作者信息

Findakly Dawood, Wang Jue

机构信息

Internal Medicine, Creighton University Arizona Health Education Alliance/Valleywise Health Medical Center, Phoenix, USA.

Genitourinary Oncology, Creighton University School of Medicine/University of Arizona Cancer Center at Dignity Health, Phoenix, USA.

出版信息

Cureus. 2020 May 29;12(5):e8356. doi: 10.7759/cureus.8356.

DOI:10.7759/cureus.8356
PMID:32494549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7263708/
Abstract

Small cell carcinoma (SCC) of the prostate is rare in the spectrum of prostate tumors. Clinically, prostate SCC is more aggressive and has a poorer prognosis when compared to prostate acinar adenocarcinoma. Delay in diagnosis and misdiagnosis further worsens the outcome of this disease. Here we present a 68-year-old man whose prostate SCC was initially misdiagnosed with benign prostate hypertrophy (BPH) by his primary care physician (PCP) and urologist and small cell lung cancer by his first oncologist and pathologist. This case underscores the diagnostic conundrum of prostate SCC and the importance of exercising caution against the possibility of uncommon prostate cancer misdiagnosis in clinical practice.

摘要

前列腺小细胞癌(SCC)在前列腺肿瘤谱系中较为罕见。临床上,与前列腺腺泡腺癌相比,前列腺SCC侵袭性更强,预后更差。诊断延迟和误诊会进一步恶化该疾病的预后。在此,我们报告一名68岁男性,其前列腺SCC最初被初级保健医生(PCP)和泌尿科医生误诊为良性前列腺增生(BPH),并被首位肿瘤学家和病理学家误诊为小细胞肺癌。该病例凸显了前列腺SCC的诊断难题,以及在临床实践中对罕见前列腺癌误诊可能性保持警惕的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/99d66ae942d9/cureus-0012-00000008356-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/4660f780e620/cureus-0012-00000008356-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/dcd2e851d19d/cureus-0012-00000008356-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/1f4738dfa078/cureus-0012-00000008356-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/40205eaae309/cureus-0012-00000008356-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/99d66ae942d9/cureus-0012-00000008356-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/4660f780e620/cureus-0012-00000008356-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/dcd2e851d19d/cureus-0012-00000008356-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/1f4738dfa078/cureus-0012-00000008356-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/40205eaae309/cureus-0012-00000008356-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7263708/99d66ae942d9/cureus-0012-00000008356-i05.jpg

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BME Front. 2022 Sep 2;2022:9847962. doi: 10.34133/2022/9847962. eCollection 2022.
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Eur Radiol. 2023 Sep;33(9):6502-6512. doi: 10.1007/s00330-023-09619-8. Epub 2023 Apr 13.

本文引用的文献

1
Epidemiology of Prostate Cancer.前列腺癌流行病学
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Rare cancers: Challenges & issues.罕见癌症:挑战与问题。
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BPH and prostate cancer risk.良性前列腺增生与前列腺癌风险。
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Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate.年龄对前列腺小细胞癌患者临床表现、治疗和癌症特异性生存的影响。
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Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway.前列腺小细胞癌的发病机制涉及 P53 通路的失活。
Endocr Relat Cancer. 2012 May 24;19(3):321-31. doi: 10.1530/ERC-11-0368. Print 2012 Jun.
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Review of small cell carcinomas of the prostate.前列腺小细胞癌综述。
Prostate Cancer. 2011;2011:543272. doi: 10.1155/2011/543272. Epub 2011 Aug 4.
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Small-cell prostate carcinoma: A retrospective analysis of five newly reported cases.小细胞前列腺癌:5例新报告病例的回顾性分析
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