Liu Baolin, Zhang Ruobing, Zhang Hong, Yu Yong, Yao Dan, Yin Shaoqiang
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
College of Chemistry, Changchun Normal University, Changchun, 130032, China.
Arch Environ Contam Toxicol. 2020 Aug;79(2):184-194. doi: 10.1007/s00244-020-00743-w. Epub 2020 Jun 3.
The widespread human exposure to perfluoroalkyl acids (PFAAs) has led to increasing public concern. In this study, we present a comprehensive measurement of total fluorine (TF), extractable organic fluorine (EOF), identified organic fluorine (IOF, total concentration of identified PFAAs quantified as fluorine) and 11 target PFAAs in human serum (n = 60), hair (n = 49) and nails (n = 39) collected from non-occupation exposed volunteers in 10 cities of Guangdong Province, China. The results indicated that EOF was the major form of fluorine in serum, accounting for 70-80% of TF. The levels of IOF contributed less than 10% of EOF. Perfluorooctane sulfonic acid (PFOS) was found to be the dominant PFAA with mean concentration of 23 ng·mL in serum, 35 ng·g in hair and 33 ng·g in nail, respectively. Short-chain PFAAs (C ≤ 10) were the predominant PFAAs in three matrices. Levels of PFOS, perfluorohexane sulfonic acid (PFHxS), perfluoroundecanoic acid (PFUdA) and perfluorotridecanoic acid (PFTrDA) in males are significantly higher than those in females (p < 0.01). Significant positive correlations were observed between nail and serum for PFOS (p < 0.01), perfluorooctanoic acid (PFOA) (p < 0.05) and PFHxS (p < 0.01), suggesting that human nails, a noninvasive sample, are a promising bio-indicator for PFAA risk assessment.
人类广泛接触全氟烷基酸（PFAA）已引发公众越来越多的关注。在本研究中，我们对从中国广东省10个城市的非职业暴露志愿者中收集的人血清（n = 60）、头发（n = 49）和指甲（n = 39）中的总氟（TF）、可提取有机氟（EOF）、鉴定出的有机氟（IOF，以氟计的鉴定出的PFAA的总浓度）和11种目标PFAA进行了全面测量。结果表明，EOF是血清中氟的主要存在形式，占TF的70 - 80%。IOF的含量占EOF的比例不到10%。全氟辛烷磺酸（PFOS）被发现是主要的PFAA，血清中平均浓度分别为23 ng·mL，头发中为35 ng·g，指甲中为33 ng·g。短链PFAA（C≤10）是三种基质中主要的PFAA。男性体内PFOS、全氟己烷磺酸（PFHxS）、全氟十一烷酸（PFUdA）和全氟十三烷酸（PFTrDA）的含量显著高于女性（p < 0.01）。观察到指甲与血清中PFOS（p < 0.01）、全氟辛酸（PFOA）（p < 0.05）和PFHxS（p < 0.01）之间存在显著正相关，这表明人指甲作为一种非侵入性样本，是PFAA风险评估的一种有前景的生物指标。
