The Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Department of Pancreatogastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China.
J Environ Sci (China). 2018 May;67:191-197. doi: 10.1016/j.jes.2017.08.017. Epub 2017 Sep 1.
The purpose of this study was to determine perfluoroalkyl substances (PFASs) in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as the biomonitoring sample for PFASs exposure. We detected the concentrations of PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoA, PFHxS and PFOS in 39 matched human serum, urine, hair and nail samples from Shenzhen in China. The detection frequency and the median level of PFOS were all higher than that of the other PFASs in four matrices. The median concentration of PFOS in serum, urine, hair, and nail were 9.24ng/mL, 13.96ng/L, 0.58ng/g and 0.63ng/g, respectively. The results of spearman correlation test indicated that nail was an ideal matrix for biomonitoring PFOS rather than human urine and hair in general populations for the non-invasive sampling.
本研究旨在测定一般人群血清、尿液、头发和指甲中的全氟烷基物质（PFASs），并探讨将人尿液、头发和指甲用作 PFASs 暴露生物监测样本的可能性。我们检测了来自中国深圳的 39 对匹配的血清、尿液、头发和指甲样本中 PFHxA、PFOA、PFNA、PFDA、PFUnDA、PFDoA、PFHxS 和 PFOS 的浓度。在四种基质中，PFOS 的检出率和中位数水平均高于其他 PFASs。血清、尿液、头发和指甲中 PFOS 的中位数浓度分别为 9.24ng/mL、13.96ng/L、0.58ng/g 和 0.63ng/g。Spearman 相关检验结果表明，指甲是生物监测 PFOS 的理想基质，而不是一般人群中用于非侵入性采样的尿液和头发。
