US Department of Health and Human Services, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, USA.
Int J Environ Health Res. 2022 Feb;32(2):437-454. doi: 10.1080/09603123.2020.1772204. Epub 2020 Jun 4.
This review utilizes the robust database of literature contained in toxicological profiles developed by the Agency for Toxic Substances and Disease Registry. The aim was to use this database to identify developmental toxicity studies reporting alterations in hormone levels in the developing fetus and offspring and identify windows of sensitivity. We identified 74 oral exposure studies in rats that provided relevant information on 30 chemicals from 21 profiles. Most studies located provided information on thyroid hormones, with fewer studies on anterior pituitary, adrenal medulla, ovaries, and testes. No studies pertaining to hormones of the posterior pituitary, pancreas, or adrenal cortex were located. The results demonstrate that development of the endocrine system may be affected by exposure to environmental contaminants at many different points, including gestational and/or lactational exposure. Moreover, this review demonstrates the need for more developmental toxicity studies focused on the endocrine system and specifically alterations in hormone levels.
本综述利用了由毒物和疾病登记署开发的毒理学简介中包含的强大文献数据库。目的是利用该数据库来识别发育毒性研究报告，这些研究报告显示了发育中的胎儿和后代的激素水平的改变，并确定了敏感窗口。我们鉴定了 74 项在大鼠中的口服暴露研究，这些研究提供了来自 21 个简介中的 30 种化学物质的相关信息。大多数定位的研究提供了关于甲状腺激素的信息，而关于前垂体、肾上腺髓质、卵巢和睾丸的研究较少。没有找到与后垂体、胰腺或肾上腺皮质的激素有关的研究。结果表明，内分泌系统的发育可能会受到环境污染物在许多不同时间点的暴露的影响，包括妊娠期和/或哺乳期的暴露。此外，本综述表明需要更多针对内分泌系统和特定的激素水平改变的发育毒性研究。
