健康影响分类及其在最低风险水平推导中的作用：生殖和内分泌影响

Health effects classification and its role in the derivation of minimal risk levels: reproductive and endocrine effects.

作者信息

Pohl Hana R, Luukinen Bryan, Holler James S

机构信息

Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA.

出版信息

Regul Toxicol Pharmacol. 2005 Jul;42(2):209-17. doi: 10.1016/j.yrtph.2005.04.004.

DOI:10.1016/j.yrtph.2005.04.004

PMID:15921838

Abstract

The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. From the total of 326 MRLs currently posted on ATSDR's web site (www.atsdr.cdc.gov), 14 and 5 MRLs are based on reproductive and endocrine endpoints, respectively. The paper also describes the ranking of effects into less serious and serious categories according to ATSDR's Guidance for Developing Toxicological Profiles, endpoints used for the MRLs derivation, and the use of uncertainty factors.

摘要

有毒物质与疾病登记署（ATSDR）制定了基于健康的指导值，即最低风险水平（MRLs），以协助评估接触有害化学物质所带来的风险。在ATSDR网站（www.atsdr.cdc.gov）目前公布的总共326个MRLs中，分别有14个和5个MRLs是基于生殖和内分泌终点得出的。本文还根据ATSDR的《毒理学概况编制指南》描述了将影响分为不太严重和严重两类的情况、用于推导MRLs的终点以及不确定性因素的使用。