IMASL-CONICET, Universidad Nacional de San Luis, Ejército de Los Andes 950, 5700 San Luis, Argentina.
J Phys Chem Lett. 2020 Jul 2;11(13):4998-4999. doi: 10.1021/acs.jpclett.0c01414. Epub 2020 Jun 12.
It is a common belief that metamorphic proteins challenge Anfinsen's thermodynamic hypothesis (or dogma). Here we argue against this view and aim to show that metamorphic proteins not only fulfill Anfinsen's dogma but also exhibit marginal stability comparable to that seen on biomolecules and macromolecular complexes. This work contributes to our general understanding of protein classification and may spur significant progress in our effort to analyze protein evolvability.
人们普遍认为，变构蛋白对 Anfinsen 的热力学假说（或教条）提出了挑战。在这里，我们反对这种观点，并旨在表明变构蛋白不仅满足 Anfinsen 的教条，而且还表现出与生物分子和大分子复合物相似的边缘稳定性。这项工作有助于我们对蛋白质分类的总体理解，并可能推动我们分析蛋白质可进化性的努力取得重大进展。
