Department of Forensic Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey.
Department of Forensic Medicine, Faculty of Medicine, University of Cukurova, Adana, Turkey.
Traffic Inj Prev. 2020;21(6):371-374. doi: 10.1080/15389588.2020.1767777. Epub 2020 Jun 4.
This study aims to explain whether EtG and EtS, which are two non-oxidative ethanol metabolites secreted by the liver and used as markers of alcohol intake related to an incident, were also present in whole blood samples of patients with traffic accident injuries. EtG and EtS concentrations in all of the whole blood samples were sent to the Forensic Medicine Department of Cukurova University for testing Blood Alcohol Concentrations (BAC) via validated liquid chromatography-tandem mass spectrometer method. The scope of the study covers 200 patients that were admitted to medical services within 12 h following the incident. Of all patients 16.5% were found to be BAC positive, while 35.5 and 23.5 were positive for EtG and EtS, respectively. All samples with a positive BAC result were also positive for EtG and EtS. Detection of EtG and EtS, minor metabolites along with ethanol in the blood can serve as an objective tool to provide further analysis regarding alcohol-related traffic accidents at emergency services.
本研究旨在解释肝分泌的两种非氧化乙醇代谢物 EtG 和 EtS 是否也存在于交通事故伤者的全血样本中，这两种代谢物被用作与事件相关的饮酒量的标志物。所有全血样本的 EtG 和 EtS 浓度均被送往库鲁瓦大学法医学系，通过经过验证的液相色谱-串联质谱法检测血液酒精浓度（BAC）。该研究范围包括 200 名在事件发生后 12 小时内接受医疗服务的患者。所有患者中有 16.5% 的 BAC 检测结果为阳性，而 EtG 和 EtS 的阳性率分别为 35.5%和 23.5%。所有 BAC 检测结果阳性的样本也均为 EtG 和 EtS 阳性。血液中 EtG 和 EtS 以及乙醇的微量代谢物的检测可以作为一种客观工具，为急诊部门的酒精相关交通事故提供进一步分析。
