Laboratorio "Dr. Fernando Canas", Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, INICSA (CONICET-Universidad Nacional de Cordoba), Pabellon Argentina, 2do. Piso, Ciudad Universitaria, 5000 Cordoba, Argentina.
Curr Med Chem. 2021;28(10):1987-2007. doi: 10.2174/0929867327666200604171351.
Naringin (NAR) is a flavonoid enriched in several medicinal plants and fruits. An increasing interest in this molecule has emerged because it has the potential to contribute to alleviating many health problems.
This review briefly describes the NAR pharmacokinetics and it mainly focuses on the in vitro and in vivo animal studies showing NAR beneficial effects on cardiovascular, metabolic, neurological and pulmonary disorders and cancer. The anabolic effects of NAR on different models of bone and dental diseases are also analyzed. In addition, the evidence of the NAR action on the gastrointestinal tract is reported as well as its influence on the microbiota composition and activity. Finally, current research on NAR formulations and clinical applications are discussed.
The PubMed database was searched until 2019, using the keywords NAR, naringenin, cardiovascular and metabolic disorders, neurological and pulmonary disorders, cancer, bone and dental diseases, gastrointestinal tract, microbiota, NAR formulations, clinical trials.
The number of studies related to the bioavailability and pharmacokinetics of NAR is limited. Positive effects of NAR have been reported on cardiovascular diseases, Type 2 Diabetes Mellitus (T2DM), metabolic syndrome, pulmonary disorders, neurodegenerative diseases, cancer, and gastrointestinal pathologies. The current NAR formulations seem to improve its bioavailability, which would allow its clinical applications.
NAR is endowed with broad biological effects that could improve human health. Since a scarce number of clinical studies have been performed, the NAR use requires more investigation in order to know better their safety, efficacy, delivery, and bioavailability in humans.
柚皮苷（NAR）是几种药用植物和水果中富含的一种类黄酮。人们对这种分子的兴趣越来越大，因为它有可能有助于缓解许多健康问题。
本文简要描述了 NAR 的药代动力学，主要关注体外和体内动物研究表明 NAR 对心血管、代谢、神经和肺部疾病以及癌症的有益作用。还分析了 NAR 对不同骨和牙科疾病模型的合成代谢作用。此外，还报告了 NAR 对胃肠道作用的证据以及它对微生物群落组成和活性的影响。最后，讨论了当前关于 NAR 制剂和临床应用的研究。
使用关键词 NAR、柚皮苷、心血管和代谢紊乱、神经和肺部疾病、癌症、骨和牙科疾病、胃肠道、微生物群、NAR 制剂、临床试验，在 PubMed 数据库中搜索至 2019 年。
与 NAR 生物利用度和药代动力学相关的研究数量有限。已报道 NAR 对心血管疾病、2 型糖尿病（T2DM）、代谢综合征、肺部疾病、神经退行性疾病、癌症和胃肠道疾病有积极作用。目前的 NAR 制剂似乎可以提高其生物利用度，从而允许其临床应用。
NAR 具有广泛的生物学效应，可以改善人类健康。由于进行的临床研究数量较少，因此需要对 NAR 的使用进行更多的研究，以便更好地了解其在人类中的安全性、疗效、给药和生物利用度。
