铜催化的乙烯基芳烃与异氰酸酯的硼酰胺化反应。
Copper-catalyzed borylamidation of vinyl arenes with isocyanates.
作者信息
Su Zhenni, Feng Yunqiu, Zou Rong, Qiu Xianfan, Wang Jian, Tao Chuanzhou
机构信息
School of Chemical Engineering, Jiangsu Ocean University, Lianyungang 222005, China.
出版信息
Chem Commun (Camb). 2020 Jul 11;56(54):7483-7486. doi: 10.1039/c9cc09902f. Epub 2020 Jun 4.
A copper-catalyzed borylative amidation of vinyl arenes with isocyanates and bis(pinacolato)diboron has been developed. This new protocol, which can be performed on a gram-scale, utilizes isocyanates as simple precursors to provide access to a range of boryl alkyl amides. The products contain valuable amide and boronate, which are amenable for further elaboration, and have versatile synthetic utilities.
已开发出一种铜催化的乙烯基芳烃与异氰酸酯和双(频哪醇)二硼的硼酰化酰胺化反应。这一新方法可进行克级规模的反应，利用异氰酸酯作为简单前体来制备一系列硼酰化烷基酰胺。产物含有有价值的酰胺和硼酸酯，易于进一步衍生化，具有多种合成用途。
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