Zhang Hao-Ran, Qiao Rui-Qi, Yang Xiong-Gang, Hu Yong-Cheng
Department of Bone Tumor, Tianjin Hospital , Tianjin, China.
Graduate School, Tianjin Medical University , Tianjin, China.
Neurol Res. 2020 Sep;42(9):749-759. doi: 10.1080/01616412.2020.1773630. Epub 2020 Jun 4.
Spinal metastases have unique epidemiological features and treatment methods. Unfortunately, the relative scarcity of spinal metastases has limited the widespread development of descriptive epidemiological studies, especially in Asian countries. The purpose of this study was to describe the epidemiological characteristics of patients with metastatic spinal tumors in China between 2007 and 2019.
From January 2007 and July 2019, data on patients with spinal metastases were collected from five cancer centers in China, and demographic characteristics, primary tumor types, segments and numbers of vertebral lesions, disease-related scores, and treatment methods were reviewed.
A total of 2228 patients with spinal metastases were reviewed in this study, including 1279 male patients and 949 female patients, and the male to female ratio was 1.35: 1. More than half of patients developed metastatic diseases between the ages of 50 years and 69 years (64%). Overall, lung cancer (824 cases, 37%) was the most common primary tumor type and the most common level of spinal involvement was multi-level of metastases (860 cases, 39%). 705 patients (32%) had undergone surgical treatments, 1028 patients (46%) had undergone radiotherapy for metastatic vertebrae, and 855 patients (38%) had received systemic treatments. The age, primary tumor type, number of involved vertebrae, Frankel grade, and spinal instability neoplastic score would affect the surgical decision-making.
This study provides insight into the epidemiological characteristics of spinal metastasis and health care service utilization in spinal metastasis patients in China.
ICD-10: International Classification of Disease, Tenth Revision; VAS: Visual Analogue Scale; KPS: Karnofsky Performance Status; SINS: Spinal Instability Neoplastic Score; SOSG: Spine Oncology Study Group; MRI: Magnetic Resonance Imaging; CT: Computed Tomography; ECT: Emission Computed Tomography.
脊柱转移瘤具有独特的流行病学特征和治疗方法。遗憾的是，脊柱转移瘤相对少见，这限制了描述性流行病学研究的广泛开展，尤其是在亚洲国家。本研究的目的是描述2007年至2019年间中国转移性脊柱肿瘤患者的流行病学特征。
收集2007年1月至2019年7月期间来自中国五个癌症中心的脊柱转移瘤患者数据，并对人口统计学特征、原发肿瘤类型、椎体病变节段和数量、疾病相关评分以及治疗方法进行回顾。
本研究共纳入2228例脊柱转移瘤患者，其中男性1279例，女性949例，男女比例为1.35:1。超过一半的患者在50岁至69岁之间发生转移性疾病（64%）。总体而言，肺癌（824例，37%）是最常见的原发肿瘤类型，最常见的脊柱受累水平是多节段转移（860例，39%）。705例患者（32%）接受了手术治疗，1028例患者（46%）接受了转移性椎体放疗，855例患者（38%）接受了全身治疗。年龄、原发肿瘤类型、受累椎体数量、Frankel分级和脊柱不稳定肿瘤评分会影响手术决策。
本研究深入了解了中国脊柱转移瘤的流行病学特征以及脊柱转移瘤患者的医疗服务利用情况。
ICD-10：国际疾病分类第十版；VAS：视觉模拟评分；KPS：卡氏功能状态评分；SINS：脊柱不稳定肿瘤评分；SOSG：脊柱肿瘤研究组；MRI：磁共振成像；CT：计算机断层扫描；ECT：发射计算机断层扫描。
