Department of Bone Tumor, Tianjin Hospital, Tianjin, China.
Graduate School, Tianjin Medical University, Tianjin, China.
Orthop Surg. 2019 Dec;11(6):1048-1053. doi: 10.1111/os.12552. Epub 2019 Nov 22.
To describe the epidemiological characteristics of patients with spinal metastases between 2007 and 2019.
Patients with spinal metastases were identified from several clinical centers in China between January 2007 and July 2019. Demographics, primary tumor types, spinal involvement, and Clinical indicators of each patient were reviewed.
A total of 1196 patients were included in this study, 717 males (59.95%) and 479 females (40.05%), with a male to female ratio of 1.50:1. Most patients (63.71%) were in the ages range of 50 to 69 years. The mean age was 58.6 ± 11.6 (range 13-89) years and the median age was 59.0 years. The average age of females was younger than that of males, and the difference was statistically significant. The proportion of male patients over 60 years old was higher than that of females, and the difference was statistically significant. The most common primary tumor was lung cancer (n = 437, 36.54%), followed by unknown origin (n = 194, 16.22%), kidney cancer (n = 78, 6.52%), breast cancer (n = 76, 6.35%), and liver/biliary cancer (n = 75, 6.27%). The most common primary tumor was lung cancer in both males and females, followed by unknown origin in males and breast cancer in females. There were 730 patients (61.04%) in the subgroup of the number<3; the highest level was lumbar vertebrae, with 250 patients (34.25%). The remaining 466 patients (38.96%) were included in the subgroup of the number ≥ 3; the highest level was tumor metastasis of multiple-level of spine, with 334 patients (71.67%). Among the 1196 patients, spinal cord injury occurred in 54.01% of patients, 76.34% of patients developed moderate and above pain, 55.69% of patients had metastatic spinal cord compression, and only 26.67% of patients had a clear history of primary tumors.
This study provided a relatively detailed description of epidemiological characteristics in spinal metastases in China, which could assist orthopaedic surgeons to understand the clinical characteristics of spinal metastases, and is of great significance in guiding clinical diagnoses and scientific research.
描述 2007 年至 2019 年间脊柱转移瘤患者的流行病学特征。
本研究从中国多家临床中心选取 2007 年 1 月至 2019 年 7 月间的脊柱转移瘤患者，回顾性分析患者的人口统计学资料、原发肿瘤类型、脊柱受累情况及临床指标。
本研究共纳入 1196 例患者，其中男性 717 例（59.95%），女性 479 例（40.05%），男女比例为 1.50:1。大多数患者（63.71%）年龄在 50 至 69 岁之间。患者平均年龄为 58.6±11.6（13-89）岁，中位年龄为 59.0 岁。女性的平均年龄小于男性，差异具有统计学意义。60 岁以上男性患者的比例高于女性，差异具有统计学意义。最常见的原发肿瘤是肺癌（n=437，36.54%），其次是不明原发肿瘤（n=194，16.22%）、肾癌（n=78，6.52%）、乳腺癌（n=76，6.35%）和肝癌/胆管癌（n=75，6.27%）。男性和女性最常见的原发肿瘤均为肺癌，其次是男性的不明原发肿瘤和女性的乳腺癌。有 730 例（61.04%）患者为转移灶数<3 个亚组；受累最高的椎体为腰椎，有 250 例（34.25%）。其余 466 例（38.96%）患者为转移灶数≥3 个亚组；受累最高的为多节段脊柱转移瘤，有 334 例（71.67%）。1196 例患者中，54.01%的患者发生脊髓损伤，76.34%的患者发生中重度疼痛，55.69%的患者发生转移性脊髓压迫，仅有 26.67%的患者有明确的原发肿瘤病史。
本研究较为详细地描述了中国脊柱转移瘤的流行病学特征，有助于骨科医生了解脊柱转移瘤的临床特征，对指导临床诊断和科学研究具有重要意义。
