Department of Psychology, University of Guelph, Guelph, Ontario, Canada.
Department of Psychology, University of Guelph, Guelph, Ontario, Canada.
Alcohol. 2020 Sep;87:79-88. doi: 10.1016/j.alcohol.2020.05.003. Epub 2020 Jun 1.
The addition of sweeteners to alcoholic beverages is thought to facilitate heavy alcohol consumption, and this may be of particular concern when the additive is high fructose corn syrup (HFCS).
Four experiments in male Sprague-Dawley rats were performed to investigate whether the addition of 25% HFCS to ethanol (5%, 10%, and 20% v/v ethanol) would alter its intraoral operant self-administration, palatability, and sensitivity to food deprivation stress.
As anticipated, HFCS drastically increased ethanol intake, and this effect appeared driven by its caloric value. Importantly, HFCS increased the persistence of operant responding following extinction in animals trained to self-administer the combination, and the addition of HFCS to ethanol changed subsequent responses to ethanol, including increased palatability and intake.
These results in rats suggest that the addition of HFCS to the list of ingredients in sweetened alcoholic beverages could play a significant role in the harmful consumption of ethanol-containing beverages.
人们认为在酒精饮料中添加甜味剂会促进大量饮酒，而当添加剂是高果糖玉米糖浆（HFCS）时，这可能尤其令人担忧。
在雄性 Sprague-Dawley 大鼠中进行了四项实验，以研究将 25%HFCS 添加到乙醇（5%、10%和 20%v/v 乙醇）中是否会改变其口腔操作性自我给药、可口性和对食物剥夺应激的敏感性。
正如预期的那样，HFCS 极大地增加了乙醇的摄入量，并且这种影响似乎是由其卡路里值驱动的。重要的是，HFCS 增加了接受联合自我给药训练的动物在消退后操作性反应的持久性，并且 HFCS 对乙醇的添加改变了随后对乙醇的反应，包括增加了可口性和摄入量。
这些大鼠的结果表明，HFCS 被添加到加糖酒精饮料的成分清单中可能会在含乙醇饮料的有害消费中发挥重要作用。
