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纽约皇后区 892 例 SARS-CoV-2 感染患者的胃肠道和肝脏表现分析。

Analysis of Gastrointestinal and Hepatic Manifestations of SARS-CoV-2 Infection in 892 Patients in Queens, NY.

机构信息

Division of Gastroenterology, New York-Presbyterian Queens Hospital, Flushing, New York.

Division of Gastroenterology, New York-Presbyterian Queens Hospital, Flushing, New York.

出版信息

Clin Gastroenterol Hepatol. 2020 Sep;18(10):2378-2379.e1. doi: 10.1016/j.cgh.2020.05.049. Epub 2020 Jun 1.

DOI:10.1016/j.cgh.2020.05.049
PMID:32497637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7263206/
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus responsible for coronavirus disease 2019 (COVID-19). The virus enters cells via the angiotensin-converting enzyme 2 receptor, which is present in enterocytes in the ileum and colon. Gastrointestinal (GI) manifestations include diarrhea, nausea, vomiting, and abdominal pain, and the prevalence of GI symptoms varies greatly, with a range between 2% and 57%. In addition, abnormal liver chemistries are reported commonly. As a medical center at the forefront of the early epidemic in the United States, we seek to contribute to the growing body of literature that outlines the gastrointestinal and hepatic manifestations of COVID-19.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)是一种 RNA 病毒,可引起 2019 年冠状病毒病(COVID-19)。该病毒通过血管紧张素转换酶 2 受体进入细胞,该受体存在于回肠和结肠的肠细胞中。胃肠道(GI)表现包括腹泻、恶心、呕吐和腹痛,GI 症状的发生率差异很大,范围在 2%至 57%之间。此外,常报告肝功能化学指标异常。作为美国疫情早期的医疗中心,我们力求为越来越多阐述 COVID-19 的胃肠道和肝脏表现的文献做出贡献。

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本文引用的文献

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Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis.新型冠状病毒肺炎患者胃肠道及肝脏受累的表现和预后:系统评价和荟萃分析。
Lancet Gastroenterol Hepatol. 2020 Jul;5(7):667-678. doi: 10.1016/S2468-1253(20)30126-6. Epub 2020 May 12.
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.一种 SARS-CoV-2 蛋白相互作用图谱揭示了药物再利用的靶标。
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