Graduate Program in Biomedical Gerontology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Front Cell Infect Microbiol. 2024 Oct 18;14:1425547. doi: 10.3389/fcimb.2024.1425547. eCollection 2024.
In this mini review, we explore the complex network of inflammatory reactions incited by SARS-CoV-2 infection, which extends its reach well beyond the respiratory domain to influence various organ systems. Synthesizing existing literature, it elucidates how the hyperinflammation observed in COVID-19 patients affects multiple organ systems leading to physiological impairments that can persist over long after the resolution of infection. By exploring the systemic manifestations of this inflammatory cascade, from acute respiratory distress syndrome (ARDS) to renal impairment and neurological sequelae, the review highlights the profound interplay between inflammation and organ dysfunction. By synthesizing recent research and clinical observations, this mini review aims to provide an overview of the systemic interactions and complications associated with COVID-19, underscoring the need for an integrated approach to treatment and management. Understanding these systemic effects is crucial for improving patient outcomes and preparing for future public health challenges.
在这篇迷你综述中，我们探讨了由 SARS-CoV-2 感染引发的炎症反应的复杂网络，它的影响范围远远超出了呼吸系统，影响到各种器官系统。通过综合现有文献，我们阐明了 COVID-19 患者中观察到的过度炎症如何影响多个器官系统，导致生理损伤，即使在感染得到解决后仍会持续很长时间。通过探讨炎症级联反应的全身表现，从急性呼吸窘迫综合征（ARDS）到肾脏损伤和神经后遗症，本综述强调了炎症和器官功能障碍之间的深刻相互作用。通过综合最近的研究和临床观察，本迷你综述旨在概述与 COVID-19 相关的全身相互作用和并发症，强调需要采取综合治疗和管理方法。了解这些全身效应对于改善患者预后和为未来的公共卫生挑战做好准备至关重要。
