John A. Paulson School of Engineering & Applied Sciences Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, United States of America.
John A. Paulson School of Engineering & Applied Sciences Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, United States of America.
Adv Drug Deliv Rev. 2020 Jan 1;153:87-108. doi: 10.1016/j.addr.2020.05.011. Epub 2020 Jun 1.
Nanoparticles offer new opportunities for the treatment of skin diseases. The barrier function of the skin poses a significant challenge for nanoparticles to permeate into the tissue, although the barrier is partially compromised in case of injury or inflammation, as in the case of skin cancer. This may facilitate the penetration of nanoparticles. Extensive research has gone into developing nanoparticles for topical delivery; however, relatively little progress has been made in translating them to the clinic for treating skin cancers. We summarize the types of skin cancers and practices in current clinical management. The review provides a comprehensive outlook of the various nanoparticle technologies tested for topical therapy of skin cancers and summarizes the obstacles that impede its progress from the bench-to-bedside. The review also aims to provide an understanding of the pathways that govern nanoparticle penetration into the skin and a critical analysis of the approaches used to study nanoparticle interactions within the tissue.
纳米颗粒为皮肤病的治疗提供了新的机会。皮肤的屏障功能对纳米颗粒渗透到组织中构成了重大挑战，尽管在皮肤癌等情况下，损伤或炎症会使屏障部分受损。这可能会促进纳米颗粒的渗透。人们已经进行了广泛的研究来开发用于局部递药的纳米颗粒；然而，将它们转化为治疗皮肤癌的临床应用方面相对进展甚微。我们总结了各种皮肤癌的类型和当前临床管理中的实践。综述提供了广泛的视角，涵盖了各种经测试用于皮肤癌局部治疗的纳米颗粒技术，并总结了阻碍其从实验室到临床应用进展的障碍。该综述还旨在提供对纳米颗粒穿透皮肤的途径的理解，并对用于研究组织内纳米颗粒相互作用的方法进行批判性分析。
