Muséum National d'Histoire Naturelle, UMR 7245, CNRS, MNHN Molécules de Communication et Adaptation des Micro-organismes (MCAM), équipe "Cyanobactéries, Cyanotoxines et Environnement", 12 rue Buffon, CP 39, 75231 Paris Cedex 05, France.
Sci Total Environ. 2020 Sep 20;736:139701. doi: 10.1016/j.scitotenv.2020.139701. Epub 2020 May 26.
Omics technologies offer unprecedented perspectives for the rational investigation of complex biological systems. Indeed, omics present the ability of offering an extensive perception of the biochemistry and physiology of the cell and of any perturbing consequences of contaminants through the joint investigation of thousands of molecular responses simultaneously; then it has recently conducted to a fervent attention by research ecotoxicologists. Beyond the presentation of latest advances, exemplified here by omics investigation of cyanobacterial deleterious effects on various fishes (at various experimental and biological scales and with various analytical tools and pipeline), the present review paper re-explores the promising perspectives and also the pitfalls of such holistic investigations of the ecotoxicological response of organisms for environmental assessment.
组学技术为合理研究复杂生物系统提供了前所未有的视角。实际上，组学通过同时联合研究数千个分子反应，提供了对细胞生物化学和生理学以及污染物任何干扰后果的广泛认识；因此，它最近引起了生态毒理学家的强烈关注。除了介绍最新进展（这里举例说明了组学研究蓝藻对各种鱼类的有害影响，包括在不同的实验和生物学尺度上，以及使用各种分析工具和流程），本文综述还重新探讨了这种对生物体生态毒理反应进行整体研究的有前途的前景和潜在问题，以用于环境评估。
