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CD4 T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4 Cells.人扁桃体和血液中的 CD4 T 滤泡辅助细胞具有克隆趋同现象，但与非 Tfh CD4 细胞不同。
Cell Rep. 2020 Jan 7;30(1):137-152.e5. doi: 10.1016/j.celrep.2019.12.016.
2
Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.抑制转录因子 ROR-γ 可减少乙酰胆碱受体抗体阳性重症肌无力中的致病性 Th17 细胞。
Exp Neurol. 2020 Mar;325:113146. doi: 10.1016/j.expneurol.2019.113146. Epub 2019 Dec 12.
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T follicular helper cells in human efferent lymph retain lymphoid characteristics.人效应淋巴中的滤泡辅助 T 细胞保留了淋巴样特征。
J Clin Invest. 2019 Jul 2;129(8):3185-3200. doi: 10.1172/JCI125628.
4
Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients.他克莫司抑制 MuSK 抗体阳性重症肌无力患者的 Th1 和 Th17 反应。
Exp Neurol. 2019 Feb;312:43-50. doi: 10.1016/j.expneurol.2018.11.006. Epub 2018 Nov 22.
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B cells in the pathophysiology of myasthenia gravis.B 细胞在重症肌无力的病理生理学中的作用。
Muscle Nerve. 2018 Feb;57(2):172-184. doi: 10.1002/mus.25973. Epub 2017 Sep 30.
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The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus.循环滤泡辅助性T细胞与滤泡调节性T细胞的比例与系统性红斑狼疮的疾病活动相关。
Clin Immunol. 2017 Oct;183:46-53. doi: 10.1016/j.clim.2017.07.004. Epub 2017 Jul 12.
7
The circulating life of a memory T-follicular helper cell.记忆性滤泡辅助性T细胞的循环寿命。
Clin Transl Immunology. 2017 May 19;6(5):e141. doi: 10.1038/cti.2017.17. eCollection 2017 May.
8
The dichotomous nature of T helper 17 cells.辅助性 T 细胞 17 细胞的双重性质。
Nat Rev Immunol. 2017 Sep;17(9):535-544. doi: 10.1038/nri.2017.50. Epub 2017 May 30.
9
Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion.老年人接种高剂量流感疫苗后外周滤泡辅助性T细胞的更强激活预示着血清转化。
Vaccine. 2017 Jan 5;35(2):329-336. doi: 10.1016/j.vaccine.2016.11.059. Epub 2016 Dec 3.
10
Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis.重症肌无力患者循环滤泡辅助性T细胞的增加及其对自身反应性B细胞的影响。
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T 滤泡辅助细胞产生白细胞介素-17 的失衡促进 MuSK 抗体阳性重症肌无力的促炎反应。

Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.

机构信息

Department of Neurology, Duke University Medical Center, Durham, NC, USA; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Department of Neurology, Duke University Medical Center, Durham, NC, USA.

出版信息

J Neuroimmunol. 2020 Aug 15;345:577279. doi: 10.1016/j.jneuroim.2020.577279. Epub 2020 May 27.

DOI:10.1016/j.jneuroim.2020.577279
PMID:32497931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7397478/
Abstract

A detailed understanding of the role of Tfh cells in MuSK-antibody positive myasthenia gravis (MuSK-MG) is lacking. We characterized phenotype and function of Tfh cells in MuSK-MG patients and controls. We found similar overall Tfh and follicular regulatory (Tfr) T cell frequencies in MuSK-MG and healthy controls, but MuSK-MG patients exhibited higher frequencies of Tfh17 cells and a higher ratio of Tfh:Tfr cells. These results suggest imbalanced Tfh cell regulation, further supported by increased frequencies of CD4 T cells co-producing IL-21/IL-17 and IL-17/IFN-γ, and increased Tfh-supported IgG production. These results support a role for Tfh cell dysregulation in MuSK-MG immunopathology.

摘要

对滤泡辅助性 T 细胞（Tfh）在抗缪勒管激素抗体阳性重症肌无力（MuSK-MG）中作用的详细了解还很缺乏。我们对 MuSK-MG 患者和对照者的 Tfh 细胞表型和功能进行了特征分析。我们发现 MuSK-MG 患者和健康对照者的总 Tfh 和滤泡调节性（Tfr）T 细胞频率相似，但 MuSK-MG 患者的 Tfh17 细胞频率更高，Tfh:Tfr 细胞比值更高。这些结果提示 Tfh 细胞调节失衡，进一步支持 CD4 T 细胞共同产生 IL-21/IL-17 和 IL-17/IFN-γ的频率增加，以及 Tfh 支持的 IgG 产生增加。这些结果支持 Tfh 细胞失调在 MuSK-MG 免疫发病机制中的作用。

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