The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nat Rev Immunol. 2017 Sep;17(9):535-544. doi: 10.1038/nri.2017.50. Epub 2017 May 30.
T helper 17 (T17) cells have been extensively studied since their discovery 10 years ago, primarily because of their known pathogenic role in many inflammatory diseases. Substantial progress has been made in understanding their development, regulation and functional activities, and genome-wide transcriptomic analysis has identified regulatory networks, nodes and interactions that provide vital clues for further studies. In this Review, we describe recent studies that have revealed the dichotomous nature of T17 cells, which on the one hand allows these cells to be pathogenic drivers of inflammatory disorders and on the other hand allows them to support the integrity of the intestinal barrier in a non-inflammatory manner.
辅助性 T 细胞 17（T17）细胞自 10 年前被发现以来，得到了广泛的研究，主要是因为它们在许多炎症性疾病中具有已知的致病作用。人们在理解它们的发育、调节和功能活动方面取得了重大进展，全基因组转录组分析确定了调节网络、节点和相互作用，为进一步的研究提供了重要线索。在这篇综述中，我们描述了最近的研究揭示了 T17 细胞的二分性，一方面使这些细胞成为炎症性疾病的致病驱动因素，另一方面使它们以非炎症的方式支持肠道屏障的完整性。
