Salisbury Dereck L, Yu Fang
J Aging Phys Act. 2020 Jun 4;28(6):911-919. doi: 10.1123/japa.2019-0387. Print 2020 Dec 1.
The purpose of this study was to investigate the relationships among peak exercise parameters on 6-min walk test, shuttle walk test, and laboratory-based cardiopulmonary exercise testing in persons with Alzheimer's dementia. This study is a cross-sectional analysis of the baseline data of 90 participants (age 77.1 [6.6] years, 43% female) from the FIT-AD trial. Cardiopulmonary exercise testing produced significantly higher peak heart rate (118.6 [17.5] vs. 106 [22.8] vs. 106 [18.8] beats/min), rating of perceived exertion (16 [2.1] vs. 12 [2.3] vs. 11 [2.1]), and systolic blood pressure (182 [23.7] vs. 156 [18.9] vs. 150 [16.9] mmHg) compared with the shuttle walk test and 6-min walk test, respectively. Peak walking distance on shuttle walk test (241.3 [127.3] m) and 6-min walk test (365.0 [107.9] m) significantly correlated with peak oxygen consumption (17.1 [4.3] ml·kg-1·min-1) on cardiopulmonary exercise testing (r = .449, p ≤ .001 and r = .435, p ≤ .001), respectively, which is considerably lower than what is seen in older adults and persons with cardiopulmonary diseases.
本研究的目的是调查阿尔茨海默病痴呆患者在6分钟步行试验、往返步行试验和基于实验室的心肺运动试验中的峰值运动参数之间的关系。本研究是对FIT-AD试验中90名参与者（年龄77.1[6.6]岁，43%为女性）的基线数据进行的横断面分析。与往返步行试验和6分钟步行试验相比，心肺运动试验产生的峰值心率（分别为118.6[17.5]对106[22.8]对106[18.8]次/分钟）、主观用力程度评分（分别为16[2.1]对12[2.3]对11[2.1]）和收缩压（分别为182[23.7]对156[18.9]对150[16.9]mmHg）显著更高。往返步行试验（241.3[127.3]米）和6分钟步行试验（365.0[107.9]米）的峰值步行距离与心肺运动试验中的峰值耗氧量（17.1[4.3]毫升·千克⁻¹·分钟⁻¹）显著相关（r = 0.449，p≤0.001和r = 0.435，p≤0.001），这显著低于老年人和心肺疾病患者的水平。
