Salisbury Dereck, Mathiason Michelle A, Yu Fang
School of Nursing, University of Minnesota Twin Cities, Minneapolis, United States.
Edison College of Nursing and Health Innovation, Arizona State University, Phoenix, United States.
Int J Sports Med. 2022 Sep;43(10):850-858. doi: 10.1055/a-1639-2307. Epub 2021 Sep 7.
The purpose of this study was to examine the effects of a 6-month cycling aerobic exercise intervention on cardiorespiratory fitness and the dose-response relationship in community-dwelling older adults with mild-to-moderate Alzheimer's dementia. The FIT-AD trial was a single blind, 2-parallel group, pilot randomized controlled trial. The aerobic exercise group participated in a 6-month, thrice weekly, moderate-vigorous intensity cycling intervention while control group performed stretching. Cardiorespiratory fitness was evaluated by peak oxygen consumption from cardiopulmonary exercise test and peak walking distance from the shuttle walk test and 6-minute walk test. Aerobic exercise dose was calculated using the novel heart rate physical activity score. The aerobic exercise group significantly increased peak oxygen consumption (1.28 ml/kg/min; p=0.03) in subgroup who achieved maximal criteria on cardiopulmonary exercise test. Changes in peak oxygen consumption and peak walking distance on the shuttle walk and 6-minute walk tests did not significantly differ between aerobic exercise and stretching groups. Notably, the aerobic exercise dose was strongly and significantly correlated to change in peak oxygen consumption (r=0.60; n=16; p=0.01), in subset who met maximal test criteria. Emphasis on exercise dose is needed in aerobic exercise programs to maximize cardiorespiratory fitness gains in persons with mild-moderate Alzheimer's dementia.
本研究旨在探讨为期6个月的骑行有氧运动干预对患有轻度至中度阿尔茨海默病痴呆症的社区老年人心肺适能及剂量反应关系的影响。FIT-AD试验是一项单盲、双平行组的试点随机对照试验。有氧运动组参加了为期6个月、每周三次的中等强度至高强度骑行干预，而对照组进行伸展运动。通过心肺运动试验中的峰值耗氧量、往返步行试验和6分钟步行试验中的峰值步行距离来评估心肺适能。使用新的心率身体活动评分来计算有氧运动剂量。在心肺运动试验中达到最大标准的亚组中，有氧运动组的峰值耗氧量显著增加（1.28毫升/千克/分钟；p=0.03）。有氧运动组和伸展运动组在往返步行试验和6分钟步行试验中的峰值耗氧量和峰值步行距离变化无显著差异。值得注意的是，在达到最大测试标准的亚组中，有氧运动剂量与峰值耗氧量的变化呈强显著相关（r=0.60；n=16；p=0.01）。有氧运动计划需要强调运动剂量，以最大限度地提高轻度至中度阿尔茨海默病痴呆症患者的心肺适能增益。
