Salisbury Dereck, Yu Fang
School of Nursing, University of Minnesota Twin Cities, Minneapolis, United States.
Sports Med Int Open. 2020 Jan 30;4(1):E1-E7. doi: 10.1055/a-1089-4957. eCollection 2020 Jan.
Evidence is growing for aerobic exercise training as a viable means to attenuate cognitive losses associated with Alzheimer's disease. The mechanism of action for aerobic exercise's cognitive benefits is likely enhanced cardiorespiratory fitness and its response to incremental aerobic exercise have been incompletely evaluated in Alzheimer's disease. The aim of this analysis was to establish cardiorespiratory fitness reference values in older adults with mild to moderate Alzheimer's disease using a cardiopulmonary graded exercise testing. Ninety-seven community-dwelling older adults with mild to moderate Alzheimer's disease underwent a symptom limited cardiopulmonary graded exercise test on a cycle ergometer. Differences between sexes and between Alzheimer's disease participants with and without diagnosis of cardiovascular diseases were assessed by independent T-tests. Peak oxygen consumption was 10-20% lower than those achieved by similar clinical populations on treadmill tests. As expected, males produced significantly higher peak oxygen consumption compared to females (p =0 .02). However, the presence of concurrent cardiovascular disease did not result in statistically significant lower peak oxygen consumption compared to those without cardiovascular disease. These data provide a frame of reference for metabolic, cardiovascular, and ventilatory function during cardiopulmonary graded exercise testing performed on cycle ergometer in older adults with mild to moderate Alzheimer's disease.
越来越多的证据表明，有氧运动训练是减轻与阿尔茨海默病相关的认知衰退的一种可行方法。有氧运动对认知有益的作用机制可能是增强心肺功能，而其对递增有氧运动的反应在阿尔茨海默病中尚未得到充分评估。本分析的目的是通过心肺运动试验确定轻度至中度阿尔茨海默病老年患者的心肺功能参考值。97名社区居住的轻度至中度阿尔茨海默病老年患者在自行车测力计上进行了症状限制性心肺运动试验。通过独立样本t检验评估性别之间以及患有和未患有心血管疾病的阿尔茨海默病参与者之间的差异。峰值耗氧量比在跑步机测试中类似临床人群的峰值耗氧量低10%-20%。正如预期的那样，男性的峰值耗氧量明显高于女性（p=0.02）。然而，与没有心血管疾病的患者相比，并发心血管疾病并没有导致峰值耗氧量在统计学上显著降低。这些数据为轻度至中度阿尔茨海默病老年患者在自行车测力计上进行心肺运动试验期间的代谢、心血管和通气功能提供了一个参考框架。
