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在强化多学科体重管理期间,患有 2 型糖尿病和超重或肥胖的患者的乳制品消费与心血管代谢危险因素:一项前瞻性观察研究。

Dairy Consumption and Cardiometabolic Risk Factors in Patients with Type 2 Diabetes and Overweight or Obesity during Intensive Multidisciplinary Weight Management: A Prospective Observational Study.

机构信息

Research Division, Joslin Diabetes Center, Boston, MA 02215, USA.

Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

出版信息

Nutrients. 2020 Jun 2;12(6):1643. doi: 10.3390/nu12061643.

Abstract

Dairy products are integral parts of healthy diets; however, their association with cardiometabolic (CM) health among patients with type 2 diabetes (T2D) undergoing weight management is debated. We examined the relationship between dairy consumption and CM biomarkers in 45 subjects with T2D and obesity (mean age 56 ± 9 yrs, 40% female) enrolled in a 12-week intensive multidisciplinary weight management (IMWM) program. After the IMWM program (intervention phase), subjects were followed for 12 weeks (maintenance phase). We stratified subjects based on initial average dairy consumption into infrequent (IFR), less-frequent (LFR), and frequent (FR) consumers. Outcomes were assessed at baseline, 12, and 24 weeks. There were no differences between tertiles at baseline except for higher total energy intake among FR compared with IFR. HbA1c changes showed no association with dairy consumption at 12 or 24 weeks. FR Females achieved greater weight loss at 12 weeks compared with IFR peers (-4.5 kg; 95%CI: -5.5, -3.5). There was a trend towards lower HDL-C with increasing dairy consumption during the intervention phase. In subjects with T2D and overweight or obesity, dairy consumption during weight management is not associated with HbA1c changes but with lower HDL-C and with higher magnitude of weight loss among females.

摘要

乳制品是健康饮食的重要组成部分;然而,对于正在进行体重管理的 2 型糖尿病(T2D)患者,其与心脏代谢(CM)健康的关系仍存在争议。我们研究了 45 名患有 T2D 和肥胖症(平均年龄 56 ± 9 岁,40%为女性)的患者中乳制品消费与 CM 生物标志物之间的关系,这些患者参加了为期 12 周的综合多学科体重管理(IMWM)计划。在 IMWM 计划(干预阶段)之后,患者在 12 周(维持阶段)内进行随访。我们根据初始平均乳制品摄入量将患者分为不频繁(IFR)、较少(LFR)和频繁(FR)消费者。在基线、12 周和 24 周评估结果。除了 FR 组的总能量摄入高于 IFR 组外,三个三分位数组在基线时没有差异。12 或 24 周时,HbA1c 的变化与乳制品摄入量无关。FR 女性在 12 周时体重减轻幅度大于 IFR 同龄人(-4.5 公斤;95%CI:-5.5,-3.5)。在干预阶段,随着乳制品摄入量的增加,HDL-C 呈下降趋势。在患有 T2D 和超重或肥胖的患者中,体重管理期间的乳制品摄入与 HbA1c 变化无关,但与较低的 HDL-C 和女性体重减轻幅度较大有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8489/7352424/e4734884e12f/nutrients-12-01643-g001.jpg

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