Wouters E F, Lándsér F J, Polko A H, Visser B F
Department of Pulmonary Diseases, University of Limburg, Maastricht, The Netherlands.
Respiration. 1988;54(4):263-70. doi: 10.1159/000195534.
Using a forced oscillation technique, the resistance and reactance of the respiratory system in a frequency range between 4 and 52 Hz were described in a group of healthy subjects and a group of patients with severe chronic obstructive pulmonary disease (COPD). In normal subjects, resistance values increased at higher frequencies. As compared to the results in normal subjects, resistance values were much higher and decreased with frequency in COPD patients. Reactance values were more negative, resulting in an increase of resonant frequency. Using matrix network topography, these findings were analyzed in a modified Mead's model. Compressibility of alveolar gas was incorporated in the model calculations. Resistance and reactance values slightly decreased by adding gas compliance in the model calculations. Our results support Mead's hypothesis that the shunt compliance is formed by the compliance of intrathoracic airway walls. Input impedance measurement by forced oscillation is therefore an easily implemented, non-invasive method to investigate respiratory mechanics not requiring active cooperation from the subject. Analysis of resistance and reactance over an extended frequency range gives information about the distribution of resistance along the bronchial system and about compliance of the intrathoracic airway walls as expanding structures in parallel with the air spaces.
采用强迫振荡技术，描述了一组健康受试者和一组重度慢性阻塞性肺疾病（COPD）患者在4至52Hz频率范围内呼吸系统的阻力和电抗。在正常受试者中，阻力值在较高频率时增加。与正常受试者的结果相比，COPD患者的阻力值更高且随频率降低。电抗值更负，导致共振频率增加。使用矩阵网络拓扑学，在改良的米德模型中分析了这些发现。肺泡气体的可压缩性被纳入模型计算。在模型计算中加入气体顺应性后，阻力和电抗值略有下降。我们的结果支持米德的假设，即分流顺应性由胸内气道壁的顺应性形成。因此，通过强迫振荡进行输入阻抗测量是一种易于实施的非侵入性方法，用于研究呼吸力学，无需受试者的主动配合。在扩展频率范围内分析阻力和电抗可提供有关支气管系统阻力分布以及胸内气道壁作为与气腔平行的扩张结构的顺应性的信息。
