Wang Le, Zhou Jia, Chen Han-Qia, Li Dong-Li, Lin Jun-Bing, Li Ke, Ding Tong-Mei, Zhang Shu-Yu
School of Biotechnology and Health Science, International Healthcare Innovation Institute, Wuyi University, Jiangmen 529020, China.
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Org Lett. 2020 Jun 19;22(12):4716-4720. doi: 10.1021/acs.orglett.0c01522. Epub 2020 Jun 4.
An efficient and benign iron-catalyzed room-temperature method was developed for direct sequential C(sp)-H/N-H annulation to construct pyrroloindole scaffolds. This strategy features cheap and readily available raw materials and mild room-temperature reaction conditions and provides a green and practical method for the one-pot rapid synthesis of a wide range of diversely functionalized pyrrolo[1,2-α]indoles.
开发了一种高效且温和的铁催化室温方法，用于直接顺序C(sp)-H/N-H环化反应以构建吡咯并吲哚骨架。该策略具有廉价且易于获得的原料以及温和的室温反应条件，为一锅快速合成多种功能多样化的吡咯并[1,2-α]吲哚提供了一种绿色且实用的方法。
