Summers R W, Flatt A J
Dept. of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa 52242.
Scand J Gastroenterol. 1988 Dec;23(10):1173-81. doi: 10.3109/00365528809090187.
The intestinal myoelectric effects of four motor-stimulating drugs were compared in conscious dogs. Dogs were fed a standardized 400-kcal meal, and the myoelectric activity was monitored before and after drug administration. Graded doses of metoclopramide, cisapride, bethanechol, and cholecystokinin (CCK) were compared by means of a computer program to identify spike bursts and determine their frequency, duration, and length of migration. Bethanechol and CCK produced the greatest increase in myoelectric activity in terms of spike burst frequency and duration but the least in terms of length of spike burst spread. Metoclopramide had minimal measurable myoelectric effects. Cisapride had the greatest effect on the length of spike burst migration but little effect on spike burst frequency and duration. The results suggest that cisapride is a more efficient prokinetic agent than bethanechol, CCK, or metoclopramide. The greater length of spike burst spread caused by cisapride was associated with a more rapid rate of transit along the monitored segment of bowel when compared with control. This confirms the correlation between length of spike burst spread and propulsive efficiency.
在清醒犬中比较了四种促动力药物的肠肌电效应。给犬喂食标准化的400千卡餐食，并在给药前后监测肌电活动。通过计算机程序比较了不同剂量的甲氧氯普胺、西沙必利、氨甲酰甲胆碱和胆囊收缩素（CCK），以识别棘波爆发并确定其频率、持续时间和迁移长度。就棘波爆发频率和持续时间而言，氨甲酰甲胆碱和CCK使肌电活动增加最多，但就棘波爆发传播长度而言增加最少。甲氧氯普胺的可测量肌电效应最小。西沙必利对棘波爆发迁移长度的影响最大，但对棘波爆发频率和持续时间影响很小。结果表明，西沙必利是一种比氨甲酰甲胆碱、CCK或甲氧氯普胺更有效的促动力剂。与对照组相比，西沙必利引起的棘波爆发传播长度更长，与沿监测肠段的转运速度更快有关。这证实了棘波爆发传播长度与推进效率之间的相关性。
