Schemann M, Ehrlein H J
Digestion. 1986;34(4):229-35. doi: 10.1159/000199335.
We investigated in conscious dogs the effects of intravenously administered 5-hydroxytryptophan (5-HTP) and cisapride on the postprandial jejunal mechanical activity by means of six closely spaced extraluminal strain gauge transducers. Drugs were given after administration of a nutrient meal. 5-HTP was given additionally after the administration of a noncaloric cellulose meal. Computer assistance was used to determine the temporal and spatial relationship of contractions and thereby to evaluate the length of spread of contractile waves. Both substances increased the propulsive activity, the contractile force and the motility index and fastened the transit rate of digesta. 5-HTP exhibited the most potent effect when given after administration of the nutrient meal.
我们通过六个紧密排列的腔外应变仪传感器，研究了静脉注射5-羟色氨酸（5-HTP）和西沙必利对清醒犬餐后空肠机械活动的影响。在给予营养餐后给药。在给予无热量纤维素餐后额外给予5-HTP。使用计算机辅助确定收缩的时间和空间关系，从而评估收缩波的传播长度。两种物质均增加了推进活动、收缩力和运动指数，并加快了消化物的通过速度。在给予营养餐后给予5-HTP时，其效果最为显著。
