Lind T, Cederberg C, Forssell H, Olausson M, Olbe L
Dept. of Surgery, Sahlgren's Hospital, Gothenburg, Sweden.
Scand J Gastroenterol. 1988 Dec;23(10):1259-66. doi: 10.3109/00365528809090202.
We have studied the relationship between reduction of gastric acid secretion and fasting plasma gastrin concentrations during once daily omeprazole treatment. Healthy subjects were given omeprazole for 5 days in daily doses of 5, 10, 20, 40, or 80 mg. Acid secretion and fasting gastrin concentration were measured 6 h (maximal omeprazole effect) and 24 h (minimal omeprazole effect) after the fifth omeprazole dose. Omeprazole in doses lower than 20 mg daily did not suppress pentagastrin-stimulated acid secretion in all subjects 6 h after dosing on the 5th day. Doses of 20-80 mg omeprazole, however, significantly reduced acid secretion 24 h after the fifth dose, the range being 36-76%. A relationship between degree of acid inhibition and fasting gastrin concentration was observed. However, acid secretion needed to be reduced by more than 80% before gastrin levels were clearly affected. This degree of acid inhibition was only achieved 6 h after administration of omeprazole in doses of 20 mg and higher. The inhibitory effect of omeprazole on acid secretion decreased 24 h after dosing. Thus, fasting gastrin concentrations were moderately increased in the beginning and normalized at the end of each 24-h period during treatment with daily doses of 20-80 mg omeprazole.
我们研究了每日一次使用奥美拉唑治疗期间胃酸分泌减少与空腹血浆胃泌素浓度之间的关系。健康受试者接受奥美拉唑治疗5天，每日剂量分别为5、10、20、40或80毫克。在第5次服用奥美拉唑后6小时（奥美拉唑最大效应）和24小时（奥美拉唑最小效应）测量胃酸分泌和空腹胃泌素浓度。每日剂量低于20毫克的奥美拉唑在第5天给药6小时后并未抑制所有受试者的五肽胃泌素刺激的胃酸分泌。然而，20 - 80毫克剂量的奥美拉唑在第5次给药24小时后显著减少了胃酸分泌，减少范围为36% - 76%。观察到胃酸抑制程度与空腹胃泌素浓度之间存在关联。然而在胃泌素水平受到明显影响之前，胃酸分泌需要减少超过80%。仅在给予20毫克及以上剂量的奥美拉唑6小时后才能达到这种程度的胃酸抑制。奥美拉唑给药24小时后对胃酸分泌的抑制作用减弱。因此，在每日剂量为20 - 80毫克的奥美拉唑治疗期间，空腹胃泌素浓度在开始时适度升高，并在每个24小时周期结束时恢复正常。
