The FEBS Journal Editorial Office, Cambridge, UK.
FEBS J. 2020 Sep;287(17):3612-3632. doi: 10.1111/febs.15442. Epub 2020 Jul 5.
The newly recognised coronavirus SARS-CoV-2, causative agent of coronavirus disease (COVID-19), has caused a pandemic with huge ramifications for human interactions around the globe. As expected, research efforts to understand the virus and curtail the disease are moving at a frantic pace alongside the spread of rumours, speculations and falsehoods. In this article, we aim to clarify the current scientific view behind several claims or controversies related to COVID-19. Starting with the origin of the virus, we then discuss the effect of ibuprofen and nicotine on the severity of the disease. We highlight the knowledge on fomites and SARS-CoV-2 and discuss the evidence and explications for a disproportionately stronger impact of COVID-19 on ethnic minorities, including a potential protective role for vitamin D. We further review what is known about the effects of SARS-CoV-2 infection in children, including their role in transmission of the disease, and conclude with the science on different mortality rates between different countries and whether this hints at the existence of more pathogenic cohorts of SARS-CoV-2.
新出现的冠状病毒 SARS-CoV-2 是导致冠状病毒病(COVID-19)的病原体,它在全球范围内造成了人类互动的巨大影响。不出所料,随着谣言、猜测和虚假信息的传播,研究人员正在加紧努力了解该病毒并遏制该疾病。在本文中,我们旨在澄清与 COVID-19 相关的几项说法或争议背后的当前科学观点。首先从病毒的起源开始,然后讨论布洛芬和尼古丁对疾病严重程度的影响。我们强调了对污染物和 SARS-CoV-2 的了解,并讨论了 COVID-19 对少数民族的影响不成比例的更强的证据和解释,包括维生素 D 可能具有保护作用。我们进一步回顾了关于 SARS-CoV-2 感染儿童的影响的知识,包括他们在疾病传播中的作用,并以不同国家之间不同死亡率的科学为结论,以及这是否暗示 SARS-CoV-2 存在更具致病性的亚群。