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1
COVID-19 breakthroughs: separating fact from fiction.新冠突破感染:区分事实与虚构。
FEBS J. 2020 Sep;287(17):3612-3632. doi: 10.1111/febs.15442. Epub 2020 Jul 5.
2
Aerosol transmission of SARS-CoV-2 by children and adults during the COVID-19 pandemic.新冠疫情期间儿童和成人通过气溶胶传播 SARS-CoV-2。
Pediatr Pulmonol. 2021 Jun;56(6):1389-1394. doi: 10.1002/ppul.25330. Epub 2021 Mar 15.
3
COVID-19 global pandemic planning: Presence of SARS-CoV-2 fomites in a university hospital setting.COVID-19 全球大流行规划:在一所大学医院环境中存在 SARS-CoV-2 污染物。
Exp Biol Med (Maywood). 2021 Sep;246(18):2039-2045. doi: 10.1177/15353702211024597. Epub 2021 Jul 4.
4
Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study.低血浆 25(OH) 维生素 D 水平与 COVID-19 感染风险增加相关:一项以色列基于人群的研究。
FEBS J. 2020 Sep;287(17):3693-3702. doi: 10.1111/febs.15495. Epub 2020 Aug 28.
5
Persistence of SARS-CoV-2: a new paradigm of COVID-19 management.SARS-CoV-2 的持续存在:COVID-19 管理的新模式。
Ann Ig. 2021 Sep-Oct;33(5):426-432. doi: 10.7416/ai.2021.2414. Epub 2021 Feb 11.
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Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection.几种膜结合丝氨酸蛋白酶对 SARS-CoV-2 S 蛋白的启动作用可以解释增强的病毒感染力和全身性 COVID-19 感染。
J Biol Chem. 2021 Jan-Jun;296:100135. doi: 10.1074/jbc.REV120.015980. Epub 2020 Dec 6.
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Is there a link between vitamin D status, SARS-CoV-2 infection risk and COVID-19 severity?维生素 D 状态与 SARS-CoV-2 感染风险和 COVID-19 严重程度之间是否存在关联?
Cell Biochem Funct. 2021 Jan;39(1):35-47. doi: 10.1002/cbf.3597. Epub 2020 Nov 2.
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V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity.SARS-CoV-2 刺突 RBD 中的 V367F 突变增强了与人类 ACE2 受体的结合亲和力,从而提高了病毒的感染性。
J Virol. 2021 Jul 26;95(16):e0061721. doi: 10.1128/JVI.00617-21.
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A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2.《COVID-19 指南:由新型冠状病毒 SARS-CoV-2 引起的全球大流行》。
FEBS J. 2020 Sep;287(17):3633-3650. doi: 10.1111/febs.15375. Epub 2020 Jun 16.
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SARS Wars: the Fomites Strike Back.非典之战:媒介物卷土重来。
Appl Environ Microbiol. 2021 Jun 11;87(13):e0065321. doi: 10.1128/AEM.00653-21.

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1
Association between coronavirus 2 infection and preeclampsia among unvaccinated women.未接种疫苗女性中2型冠状病毒感染与子痫前期之间的关联。
Rev Bras Ginecol Obstet. 2025 Jul 15;47. doi: 10.61622/rbgo/2025rbgo36. eCollection 2025.
2
Perceived accessibility, and adequacy of COVID-19 related information in Nigeria.尼日利亚民众对新冠疫情相关信息的可获取性及充分性的认知。
J Public Health Afr. 2022 Jul 27;13(2):2011. doi: 10.4081/jphia.2022.2011. eCollection 2022 Jul 26.
3
Association of Built Environmental Features with Rates of Infectious Diseases in Remote Indigenous Communities in the Northern Territory, Australia.澳大利亚北领地偏远原住民社区建筑环境特征与传染病发病率的关联
Healthcare (Basel). 2022 Jan 17;10(1):173. doi: 10.3390/healthcare10010173.
4
'It's possibly made us feel a little more alienated': How people from ethnic minority communities conceptualise COVID-19 and its influence on engagement with testing.“这可能让我们感到更加疏远”:少数民族社区的人如何看待 COVID-19 及其对检测参与的影响。
J Health Serv Res Policy. 2022 Apr;27(2):141-150. doi: 10.1177/13558196211054961. Epub 2022 Jan 3.
5
COVID-19-associated venous thromboembolism portends worse survival.与新冠病毒疾病相关的静脉血栓栓塞预示着更差的生存率。
Semin Vasc Surg. 2021 Sep;34(3):117-124. doi: 10.1053/j.semvascsurg.2021.08.001. Epub 2021 Aug 9.
6
Spotlight on COVID-19: eighteen months on.聚焦 COVID-19:十八个月过去了。
FEBS J. 2021 Sep;288(17):4992-4995. doi: 10.1111/febs.16167.
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The Role of the Health Coach in a Global Pandemic.健康教练在全球大流行中的作用。
Glob Adv Health Med. 2021 Aug 9;10:21649561211039456. doi: 10.1177/21649561211039456. eCollection 2021.
8
The possible benefits of vitamin D in COVID-19.维生素 D 在 COVID-19 中的可能益处。
Nutrition. 2021 Nov-Dec;91-92:111356. doi: 10.1016/j.nut.2021.111356. Epub 2021 May 26.
9
COVID-19 vaccines: what do we know so far?新冠疫苗:我们目前了解多少?
FEBS J. 2021 Sep;288(17):4996-5009. doi: 10.1111/febs.16094. Epub 2021 Jul 19.
10
Mitigating the identity and health threat of COVID-19: Perspectives of middle-class South Asians living in the UK.减轻 COVID-19 带来的身份和健康威胁:在英生活的中产阶级南亚裔的观点。
J Health Psychol. 2022 Aug;27(9):2147-2160. doi: 10.1177/13591053211027626. Epub 2021 Jun 22.

本文引用的文献

1
On the origin and continuing evolution of SARS-CoV-2.关于严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的起源及持续进化
Natl Sci Rev. 2020 Jun;7(6):1012-1023. doi: 10.1093/nsr/nwaa036. Epub 2020 Mar 3.
2
Why snakes probably aren't spreading the new China virus.为何蛇类可能并非新型中国病毒的传播源。 需要说明的是,将新冠病毒称为“中国病毒”是完全错误和不公正的污名化称呼,新冠病毒是全人类共同的敌人,溯源工作应基于科学,而不应被政治化操弄。
Nature. 2020 Jan 23. doi: 10.1038/d41586-020-00180-8.
3
Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo.患者来源的新型冠状病毒突变影响病毒在体外的复制动力学和传染性,并在体内具有临床意义。
Cell Discov. 2020 Oct 29;6(1):76. doi: 10.1038/s41421-020-00226-1.
4
Vitamin D and SARS-CoV-2 virus/COVID-19 disease.维生素D与严重急性呼吸综合征冠状病毒2/冠状病毒病19
BMJ Nutr Prev Health. 2020 May 13;3(1):106-110. doi: 10.1136/bmjnph-2020-000089. eCollection 2020.
5
Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank.英国生物银行新冠患者的临床、区域和遗传特征。
PLoS One. 2020 Nov 17;15(11):e0241264. doi: 10.1371/journal.pone.0241264. eCollection 2020.
6
Stability of SARS-CoV-2 on environmental surfaces and in human excreta.严重急性呼吸综合征冠状病毒2(SARS-CoV-2)在环境表面和人类排泄物中的稳定性。
J Hosp Infect. 2021 Jan;107:105-107. doi: 10.1016/j.jhin.2020.10.021. Epub 2020 Nov 1.
7
Detection of SARS-CoV-2 RNA on public surfaces in a densely populated urban area of Brazil: A potential tool for monitoring the circulation of infected patients.在巴西人口密集城区公共表面检测 SARS-CoV-2 RNA:监测感染患者传播的潜在工具。
Sci Total Environ. 2021 Apr 20;766:142645. doi: 10.1016/j.scitotenv.2020.142645. Epub 2020 Oct 2.
8
Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium.2 型糖尿病和干扰素炎症调节气道上皮细胞中的 SARS-CoV-2 进入因子表达。
Nat Commun. 2020 Oct 12;11(1):5139. doi: 10.1038/s41467-020-18781-2.
9
Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis.无症状和出现症状前 SARS-CoV-2 感染的发生和传播潜力:一项实时系统评价和荟萃分析。
PLoS Med. 2020 Sep 22;17(9):e1003346. doi: 10.1371/journal.pmed.1003346. eCollection 2020 Sep.
10
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.冠状病毒抗体介导免疫的系统评价:动力学、保护相关性及与严重程度的关系。
Nat Commun. 2020 Sep 17;11(1):4704. doi: 10.1038/s41467-020-18450-4.

新冠突破感染:区分事实与虚构。

COVID-19 breakthroughs: separating fact from fiction.

机构信息

The FEBS Journal Editorial Office, Cambridge, UK.

出版信息

FEBS J. 2020 Sep;287(17):3612-3632. doi: 10.1111/febs.15442. Epub 2020 Jul 5.

DOI:10.1111/febs.15442
PMID:32500928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7300672/
Abstract

The newly recognised coronavirus SARS-CoV-2, causative agent of coronavirus disease (COVID-19), has caused a pandemic with huge ramifications for human interactions around the globe. As expected, research efforts to understand the virus and curtail the disease are moving at a frantic pace alongside the spread of rumours, speculations and falsehoods. In this article, we aim to clarify the current scientific view behind several claims or controversies related to COVID-19. Starting with the origin of the virus, we then discuss the effect of ibuprofen and nicotine on the severity of the disease. We highlight the knowledge on fomites and SARS-CoV-2 and discuss the evidence and explications for a disproportionately stronger impact of COVID-19 on ethnic minorities, including a potential protective role for vitamin D. We further review what is known about the effects of SARS-CoV-2 infection in children, including their role in transmission of the disease, and conclude with the science on different mortality rates between different countries and whether this hints at the existence of more pathogenic cohorts of SARS-CoV-2.

摘要

新出现的冠状病毒 SARS-CoV-2 是导致冠状病毒病(COVID-19)的病原体,它在全球范围内造成了人类互动的巨大影响。不出所料,随着谣言、猜测和虚假信息的传播,研究人员正在加紧努力了解该病毒并遏制该疾病。在本文中,我们旨在澄清与 COVID-19 相关的几项说法或争议背后的当前科学观点。首先从病毒的起源开始,然后讨论布洛芬和尼古丁对疾病严重程度的影响。我们强调了对污染物和 SARS-CoV-2 的了解,并讨论了 COVID-19 对少数民族的影响不成比例的更强的证据和解释,包括维生素 D 可能具有保护作用。我们进一步回顾了关于 SARS-CoV-2 感染儿童的影响的知识,包括他们在疾病传播中的作用,并以不同国家之间不同死亡率的科学为结论,以及这是否暗示 SARS-CoV-2 存在更具致病性的亚群。