Belančić Andrej, Kresović Andrea, Rački Valentino
Department of Clinical Pharmacology, University Hospital Centre Rijeka, Krešimirova 42, 51000, Rijeka, Croatia.
Department of Gastroenterology, University Hospital Centre Rijeka, Krešimirova 42, 51000, Rijeka, Croatia.
Obes Med. 2020 Sep;19:100259. doi: 10.1016/j.obmed.2020.100259. Epub 2020 May 26.
As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflammation, higher expression of angiotensin converting enzyme-2 and pathway-associated components, as well as decreased vitamin D bioavailability, since all of them provide easier ways for the virus to enter into host cells, replicate and stunt adequate immune responses.
由于我们正面临新型冠状病毒肺炎（COVID-19）的全球大流行，我们旨在确定导致肥胖人群对COVID-19易感性增加和病情加重的潜在病理生理机制。将特别强调肥胖相关的低度慢性炎症导致的感染易感性增加、血管紧张素转换酶2及其相关通路成分的高表达，以及维生素D生物利用度降低，因为所有这些因素都为病毒进入宿主细胞、复制并抑制适当的免疫反应提供了更便利的途径。
