抗苗勒管激素作为最常见肌营养不良症女性的卵巢储备标志物。
Anti-Müllerian hormone as an ovarian reserve marker in women with the most frequent muscular dystrophies.
作者信息
Parmova Olesja, Vlckova Eva, Hulova Monika, Mensova Livie, Crha Igor, Stradalova Petra, Kralickova Eva, Jurikova Lenka, Podborska Martina, Mazanec Radim, Dusek Ladislav, Jarkovsky Jiri, Bednarik Josef, Vohanka Stanislav, Srotova Iva
机构信息
Department of Neurology, University Hospital Brno.
Faculty of Medicine, Masaryk University, Brno.
出版信息
Medicine (Baltimore). 2020 Jun 5;99(23):e20523. doi: 10.1097/MD.0000000000020523.
Some muscular dystrophies may have a negative impact on fertility. A decreased ovarian reserve is 1 of the factors assumed to be involved in fertility impairment. AMH (anti-Müllerian hormone) is currently considered the best measure of ovarian reserve.A total of 21 females with myotonic dystrophy type 1 (MD1), 25 females with myotonic dystrophy type 2 (MD2), 12 females with facioscapulohumeral muscular dystrophy (FSHD), 12 female carriers of Duchenne muscular dystrophy mutations (cDMD) and 86 age-matched healthy controls of reproductive age (range 18 - 44 years) were included in this case control study. An enzymatically amplified 2-site immunoassay was used to measure serum AMH level.The MD1 group shows a significant decrease of AMH values (median 0.7 ng/mL; range 0 - 4.9 ng/mL) compared with age-matched healthy controls (P < .01). AMH levels were similar between patients and controls in terms of females with MD2 (P = .98), FSHD (P = .55) and cDMD (P = .60).This study suggests decreased ovarian reserve in women with MD1, but not in MD2, FSHD and cDMD.
一些肌营养不良症可能会对生育能力产生负面影响。卵巢储备功能下降被认为是导致生育能力受损的因素之一。抗苗勒管激素（AMH）目前被认为是评估卵巢储备功能的最佳指标。本病例对照研究纳入了21名1型强直性肌营养不良症（MD1）女性、25名2型强直性肌营养不良症（MD2）女性、12名面肩肱型肌营养不良症（FSHD）女性、12名杜氏肌营养不良症突变携带者（cDMD）女性以及86名年龄匹配的育龄期健康对照者（年龄范围18 - 44岁）。采用酶联免疫法检测血清AMH水平。与年龄匹配的健康对照者相比，MD1组的AMH值显著降低（中位数为0.7 ng/mL；范围为0 - 4.9 ng/mL）（P < 0.01）。MD2女性患者、FSHD女性患者和cDMD女性患者的AMH水平与对照者相似（P = 0.98、P = 0.55、P = 0.60）。本研究表明，MD1女性患者的卵巢储备功能下降，而MD2、FSHD和cDMD女性患者则不然。
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