Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Biomed Pharmacother. 2020 Aug;128:110301. doi: 10.1016/j.biopha.2020.110301. Epub 2020 Jun 2.
Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the effects of cardiovascular and cerebrovascular protection, anti-tumor, anti-inflammatory, anti-oxidation, organ protection, prevention of obesity, etc. The related mechanisms involve the regulation of PI3K/AKT/PKB, NF-κB, MAPK and other signaling pathways as well as the expression of related cytokines and kinases. Isorhamnetin has a high value of development and application. However, the investigations on its mechanism of action are limited and lack of detailed scientific validation. The manuscript reviewed the pharmacological effects of isorhamnetin and related mechanisms of action for the development of its medicinal properties further.
山柰酚是沙棘果实和银杏叶中最重要的活性成分之一，具有广泛的药理活性。目前，已经有大量关于山柰酚的研究，其具有心血管和脑血管保护、抗肿瘤、抗炎、抗氧化、器官保护、预防肥胖等作用。相关机制涉及调节 PI3K/AKT/PKB、NF-κB、MAPK 等信号通路以及相关细胞因子和激酶的表达。山柰酚具有很高的开发和应用价值。然而，其作用机制的研究还很有限，缺乏详细的科学验证。本文综述了山柰酚的药理作用及其相关作用机制，以期进一步开发其药用价值。
