国际癌症研讨会摘要，重点讨论人乳头瘤病毒（HPV）阳性口咽癌，由 IARC 和 NCI 的科学家召集。
Summary from an international cancer seminar focused on human papillomavirus (HPV)-positive oropharynx cancer, convened by scientists at IARC and NCI.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, United States.
Catalan Institute of Oncology (ICO), IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; Epidemiology and Public Health, Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
出版信息
Oral Oncol. 2020 Sep;108:104736. doi: 10.1016/j.oraloncology.2020.104736. Epub 2020 Jun 2.
Cancer of the oropharynx has attracted considerable attention in recent years given: (1) an increasing incidence in selected populations over the past three decades; (2) the discovery of human papillomavirus (HPV) infection as the driver of the increase, as opposed to the traditional risk factors such as tobacco (smoking and chewing) and alcohol; and (3) the promise of new prevention and treatment strategies. As a result of such developments, the International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI), convened the fourth Cancer Seminar meeting in November 2018 to focus on this topic. This report summarizes the proceedings: a review of recent science on the descriptive epidemiology, etiology, biology, genetics, early detection, pathology and treatment of HPV-positive oropharyngeal cancer, and the formulation of key research questions to be addressed.
近年来，口咽癌受到了相当多的关注，原因如下：（1）在过去三十年中，某些人群的发病率不断上升；（2）发现人乳头瘤病毒（HPV）感染是发病率上升的驱动因素，而不是传统的危险因素，如烟草（吸烟和咀嚼）和酒精；（3）有新的预防和治疗策略的前景。由于这些发展，国际癌症研究机构（IARC）和美国国家癌症研究所（NCI）于 2018 年 11 月召开了第四次癌症研讨会，专门讨论这个话题。本报告总结了会议的议事情况：回顾了关于 HPV 阳性口咽癌的描述性流行病学、病因学、生物学、遗传学、早期检测、病理学和治疗的最新科学，并提出了需要解决的关键研究问题。
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