Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Desk R-35, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Curr Oncol Rep. 2010 Mar;12(2):115-20. doi: 10.1007/s11912-010-0084-5.
The human papillomavirus (HPV) has recently been identified as an important etiologic agent in the development of squamous cell carcinoma of the oropharynx. The HPV- associated cancers appear to have a different biology than the HPV-negative cancers, and affect a population that is more likely to be young, male, Caucasian, and nonsmoking. More importantly, however, is the recognition that patients with an HPV-associated oropharyngeal cancer have a distinctly better survival after treatment than those patients with HPV-negative tumors, although their prognosis is significantly worse if there is a history of tobacco abuse. HPV-associated oropharynx cancer should be recognized as a new biologic entity and studied separately from HPV-negative cancers in future clinical trials. The potential for disease prevention with the use of the current HPV vaccines is discussed.
人乳头瘤病毒（HPV）最近被确定为口咽鳞状细胞癌发展的重要病因。与 HPV 阴性癌症相比，HPV 相关癌症似乎具有不同的生物学特性，并且影响的人群更年轻、男性、白种人且不吸烟。然而，更重要的是，人们认识到患有 HPV 相关口咽癌的患者在治疗后存活的几率明显高于 HPV 阴性肿瘤患者，尽管如果有烟草滥用史，其预后则显著更差。HPV 相关口咽癌应被视为一种新的生物学实体，并在未来的临床试验中与 HPV 阴性癌症分开研究。还讨论了使用当前 HPV 疫苗预防疾病的潜力。
