近红外（NIR）成像：探索镧系配合物的生物学相关化学空间。
Near Infrared (NIR) imaging: Exploring biologically relevant chemical space for lanthanide complexes.
机构信息
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China.
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China; School of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, PR China.
出版信息
J Inorg Biochem. 2020 Aug;209:111118. doi: 10.1016/j.jinorgbio.2020.111118. Epub 2020 May 23.
Near Infrared (NIR) imaging agents are extensively used in the biological or preclinical treatment and diagnosis of a wide range of diseases including cancers and tumors. The current arsenal of NIR compounds are most constituted by organic dyes, polymers, inorganic nanomaterials, whereas Ln molecular complexes explore an alternative approach to design NIR probes that are potentially bring new molecular toolkits into the biomedicine. In this review, NIR imaging agents are categorized according to their molecular sizes, constitution and the key properties and features of each class of compounds are briefly defined wherever possible. To better elucidate the features of Ln complexes, we provide a succinct understanding of sensitization process and molecular Ln luminescence at a mechanistic level, which may help to deliver new insights to design NIR imaging probes. Finally, we used our work on NIR ytterbium (Yb) probes as an example to raise awareness of exploring biologically relevant chemical space for lanthanide complexes as chemical entities for biological activity.
近红外（NIR）成像剂广泛应用于癌症和肿瘤等多种疾病的生物或临床前治疗和诊断。目前的 NIR 化合物主要由有机染料、聚合物、无机纳米材料组成，而镧系分子配合物则探索了设计 NIR 探针的另一种方法，有可能为生物医学带来新的分子工具包。在这篇综述中，根据分子大小、组成对 NIR 成像剂进行了分类，并尽可能简要地定义了每一类化合物的关键性质和特征。为了更好地阐明镧系配合物的特点，我们在机制水平上提供了对敏化过程和分子镧系发光的简洁理解，这可能有助于为设计 NIR 成像探针提供新的见解。最后，我们以我们在 NIR 镱（Yb）探针上的工作为例，引起人们对探索生物相关化学空间的认识，将镧系配合物作为生物活性的化学实体。
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