Fan Qi, Sun Chao, Hu Bingliang, Wang Quan
Key Laboratory of Spectral Imaging Technology, Xi'an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi'an, 710119, China.
Key Laboratory of Biomedical Spectroscopy of Xi'an, Key Laboratory of Spectral Imaging Technology, Xi'an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi'an, 710119, China.
Mater Today Bio. 2023 May 2;20:100646. doi: 10.1016/j.mtbio.2023.100646. eCollection 2023 Jun.
Lanthanide nanomaterials have garnered significant attention from researchers among the main near-infrared (NIR) fluorescent nanomaterials due to their excellent chemical and fluorescence stability, narrow emission band, adjustable luminescence color, and long lifetime. In recent years, with the preparation, functional modification, and fluorescence improvement of lanthanide materials, great progress has been made in their application in the biomedical field. This review focuses on the latest progress of lanthanide nanomaterials in tumor diagnosis and treatment, as well as the interaction mechanism between fluorescence and biological tissues. We introduce a set of efficient strategies for improving the fluorescence properties of lanthanide nanomaterials and discuss some representative in-depth research work in detail, showcasing their superiority in early detection of ultra-small tumors, phototherapy, and real-time guidance for surgical resection. However, lanthanide nanomaterials have only realized a portion of their potential in tumor applications so far. Therefore, we discuss promising methods for further improving the performance of lanthanide nanomaterials and their future development directions.
镧系纳米材料作为主要的近红外（NIR）荧光纳米材料之一，因其优异的化学和荧光稳定性、窄发射带、可调节的发光颜色以及长寿命而受到研究人员的广泛关注。近年来，随着镧系材料的制备、功能修饰和荧光性能的提升，它们在生物医学领域的应用取得了巨大进展。本综述聚焦于镧系纳米材料在肿瘤诊断与治疗方面的最新进展，以及荧光与生物组织之间的相互作用机制。我们介绍了一系列提高镧系纳米材料荧光性能的有效策略，并详细讨论了一些具有代表性的深入研究工作，展示了它们在超小肿瘤早期检测、光疗以及手术切除实时引导方面的优势。然而，镧系纳米材料目前在肿瘤应用中仅实现了部分潜力。因此，我们讨论了进一步提高镧系纳米材料性能的有前景的方法及其未来发展方向。
