Yang Yingjie, Tu Datao, Zhang Yunqin, Zhang Peng, Chen Xueyuan
CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
iScience. 2021 Jan 20;24(2):102062. doi: 10.1016/j.isci.2021.102062. eCollection 2021 Feb 19.
Luminescent biosensing in the second near-infrared window (NIR-II, 1000-1700 nm) region, which has weak tissue scattering and low autofluorescence, draws extensive attention owing to its deep tissue penetration, good spatial resolution and high signal-to-background ratio. As a new generation of NIR-II probes, lanthanide (Ln)-containing nanoprobes exhibit several superior properties. With the rapid development of Ln-containing NIR-II nanoprobes, many significant advances have been accomplished in their optical properties tuning and surface functional modification for further bioapplications. Rather than being exhaustive, this review aims to survey the recent advances in the design strategies of inorganic Ln-containing NIR-II luminescent nanoprobes by highlighting their optical performance optimization and surface modification approaches. Moreover, challenges and opportunities for this kind of novel NIR-II nanoprobes are envisioned.
在第二近红外窗口（NIR-II，1000 - 1700纳米）区域进行的发光生物传感，由于其组织散射较弱、自发荧光较低，且具有深层组织穿透能力、良好的空间分辨率和高信噪比，因而备受广泛关注。作为新一代的NIR-II探针，含镧系元素（Ln）的纳米探针展现出若干优异特性。随着含Ln的NIR-II纳米探针的快速发展，在其光学性质调控和表面功能修饰以用于进一步生物应用方面已取得了许多重大进展。本综述并非详尽无遗，而是旨在通过突出无机含Ln的NIR-II发光纳米探针的光学性能优化和表面修饰方法，来审视其设计策略的最新进展。此外，还展望了这类新型NIR-II纳米探针所面临的挑战和机遇。
