Vilmane Anda, Terentjeva Anna, Tamosiunas Paulius L, Suna Normunds, Suna Inga, Petraityte-Burneikiene Rasa, Murovska Modra, Rasa-Dzelzkaleja Santa, Nora-Krukle Zaiga
Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites St., LV-1067 Riga, Latvia.
Vilnius University Life Sciences Center Institute of Biotechnology, 7 Sauletekio Al., 10257 Vilnius, Lithuania.
Brain Sci. 2020 Jun 3;10(6):339. doi: 10.3390/brainsci10060339.
Meningitis and meningoencephalitis are neurological inflammatory diseases, and although routine diagnostics include testing of a wide range of pathogens, still in many cases, no causative agent is detected. Human parvovirus B19 (B19V), human bocaviruses 1-4 (HBoV1-4), and human parvovirus 4 (hPARV4) are members of the family and are associated with a wide range of clinical manifestations including neurological disorders. The main aim of this study was to determine whether human parvoviruses infection markers are present among patients with meningitis/meningoencephalitis in Latvia as well as to clarify the role of these viruses on the clinical course of the mentioned diseases. Our study revealed HBoV1-4 and B19V genomic sequences in 52.38% and 16.67% of patients, respectively. Furthermore, symptoms such as the presence of a headache and its severity, fatigue, disorientation, and difficulties to concentrate were significantly frequently present in patients with active parvovirus infection in comparison with parvoviruses negative patients, therefore we suggest that HBoV1-4 and B19V infection should be included in the diagnostics to reduce the number of meningitis/meningoencephalitis with unknown/unexplained etiology.
脑膜炎和脑膜脑炎是神经性炎症性疾病，尽管常规诊断包括检测多种病原体，但在许多情况下，仍未检测到病原体。人细小病毒B19（B19V）、人博卡病毒1-4（HBoV1-4）和人细小病毒4（hPARV4）是该病毒家族的成员，与包括神经系统疾病在内的多种临床表现有关。本研究的主要目的是确定拉脱维亚脑膜炎/脑膜脑炎患者中是否存在人细小病毒感染标志物，并阐明这些病毒在上述疾病临床过程中的作用。我们的研究分别在52.38%和16.67%的患者中发现了HBoV1-4和B19V基因组序列。此外，与细小病毒阴性患者相比，活动性细小病毒感染患者中头痛及其严重程度、疲劳、定向障碍和注意力不集中等症状明显更常见，因此我们建议在诊断中应包括HBoV1-4和B19V感染检测，以减少病因不明/无法解释的脑膜炎/脑膜脑炎病例数量。
