Department of Nutrition, University of Nevada Reno, Reno, NV 89557, USA.
Department of Biomedical Sciences, Midwestern University, Downers Grove, IL 60515, USA.
Int J Mol Sci. 2020 Jun 3;21(11):4006. doi: 10.3390/ijms21114006.
Cardiovascular diseases (CVD) are the main cause of death worldwide and create a substantial financial burden. Emerging studies have begun to focus on epigenetic targets and re-establishing healthy gut microbes as therapeutic options for the treatment and prevention of CVD. Phytochemicals, commonly found in fruits and vegetables, have been shown to exert a protective effect against CVD, though their mechanisms of action remain incompletely understood. Of interest, phytochemicals such as curcumin, resveratrol and epigallocatechin gallate (EGCG) have been shown to regulate both histone acetylation and microbiome re-composition. The purpose of this review is to highlight the microbiome-epigenome axis as a therapeutic target for food bioactives in the prevention and/or treatment of CVD. Specifically, we will discuss studies that highlight how the three phytochemicals above alter histone acetylation leading to global changes in gene expression and CVD protection. Then, we will expand upon these phytochemicals to discuss the impact of phytochemical-microbiome-histone acetylation interaction in CVD.
心血管疾病 (CVD) 是全球主要死因，造成巨大的经济负担。新出现的研究开始关注表观遗传靶点，并将恢复健康的肠道微生物作为治疗和预防 CVD 的治疗选择。植物化学物质，常见于水果和蔬菜，已被证明对 CVD 具有保护作用，尽管其作用机制仍不完全清楚。有趣的是，姜黄素、白藜芦醇和表没食子儿茶素没食子酸酯 (EGCG) 等植物化学物质已被证明可以调节组蛋白乙酰化和微生物组的重新组成。本综述的目的是强调微生物组-表观基因组轴作为预防和/或治疗 CVD 的食物生物活性的治疗靶点。具体来说，我们将讨论强调上述三种植物化学物质如何改变组蛋白乙酰化导致基因表达的全局变化并保护 CVD 的研究。然后，我们将扩展这些植物化学物质的讨论，讨论植物化学物质-微生物组-组蛋白乙酰化相互作用对 CVD 的影响。
