Souza-Peres Joao Victor, Flores Kimberly, Umloff Bethany, Heinan Michelle, Herscu Paul, Babos Mary Beth
DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USA.
School of Medical Sciences, Lincoln Memorial University, Harrogate, TN 37752, USA.
Medicines (Basel). 2023 Feb 28;10(3):20. doi: 10.3390/medicines10030020.
A lack of reliable information hinders the clinician evaluation of suspected herb-drug interactions. This pilot study was a survey-based study conceived as a descriptive analysis of real-life experiences with herb-drug interaction from the perspective of herbalists, licensed health-care providers, and lay persons. Reported dietary supplement-drug interactions were evaluated against the resources most commonly cited for the evaluation of potential supplement-drug interactions. Disproportionality analyses were performed using tools available to most clinicians using data from the U.S. Federal Adverse Event Reporting System (FAERS) and the US Center for Food Safety and Applied Nutrition (CFSAN) Adverse Event Reporting System (CAERS). Secondary aims of the study included exploration of the reasons for respondent use of dietary supplements and qualitative analysis of respondent's perceptions of dietary supplement-drug interaction. While agreement among reported supplement-drug interactions with commonly cited resources for supplement-drug interaction evaluation and via disproportionality analyses through FAERS was low, agreement using data from CAERS was high.
缺乏可靠信息阻碍了临床医生对疑似草药-药物相互作用的评估。这项初步研究是一项基于调查的研究，旨在从草药师、持牌医疗保健提供者和普通民众的角度，对草药-药物相互作用的实际生活经验进行描述性分析。针对评估潜在补充剂-药物相互作用时最常引用的资源，对报告的膳食补充剂-药物相互作用进行了评估。使用大多数临床医生都能使用的工具，利用来自美国联邦不良事件报告系统（FAERS）和美国食品安全与应用营养中心（CFSAN）不良事件报告系统（CAERS）的数据进行了不成比例分析。该研究的次要目标包括探究受访者使用膳食补充剂的原因，以及对受访者对膳食补充剂-药物相互作用的认知进行定性分析。虽然报告的补充剂-药物相互作用与补充剂-药物相互作用评估的常用引用资源之间的一致性较低，且通过FAERS进行的不成比例分析得出的一致性也较低，但使用CAERS数据得出的一致性较高。
