Ismaiel Abdulrahman, Spinu Mihail, Budisan Livia, Leucuta Daniel-Corneliu, Popa Stefan-Lucian, Chis Bogdan Augustin, Berindan-Neagoe Ioana, Olinic Dan Mircea, Dumitrascu Dan L
2nd Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Medical Clinic No. 1, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
J Clin Med. 2021 Nov 7;10(21):5194. doi: 10.3390/jcm10215194.
(1) Background: The role of adipokines such as adiponectin and visfatin in metabolic-dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease remains unclear. Therefore, we aim to assess serum adiponectin and visfatin levels in MAFLD patients and associated cardiovascular parameters. (2) Methods: A cross-sectional study involving 80 participants (40 MAFLD patients, 40 controls), recruited between January and September 2020, was conducted, using both hepatic ultrasonography and SteatoTestTM to evaluate hepatic steatosis. Echocardiographic and Doppler parameters were assessed. Serum adipokines were measured using ELISA kits. (3) Results: Adiponectin and visfatin levels were not significantly different in MAFLD vs. controls. Visfatin was associated with mean carotid intima-media thickness (-value = 0.047), while adiponectin was associated with left ventricular ejection fraction (LVEF) (-value = 0.039) and E/A ratio (-value = 0.002) in controls. The association between adiponectin and E/A ratio was significant in the univariate analysis at 95% CI (0.0049-0.1331, -value = 0.035), but lost significance after the multivariate analysis. Although LVEF was not associated with adiponectin in the univariate analysis, significant values were observed after the multivariate analysis (95% CI (-1.83--0.22, -value = 0.015)). (4) Conclusions: No significant difference in serum adiponectin and visfatin levels in MAFLD patients vs. controls was found. Interestingly, although adiponectin levels were not associated with LVEF in the univariate analysis, a significant inversely proportional association was observed after the multivariate analysis.
（1）背景：脂联素和内脂素等脂肪因子在代谢功能障碍相关脂肪性肝病（MAFLD）和心血管疾病中的作用仍不明确。因此，我们旨在评估MAFLD患者的血清脂联素和内脂素水平以及相关的心血管参数。（2）方法：进行了一项横断面研究，纳入了2020年1月至9月招募的80名参与者（40名MAFLD患者，40名对照），使用肝脏超声检查和SteatoTestTM评估肝脂肪变性。评估了超声心动图和多普勒参数。使用ELISA试剂盒测量血清脂肪因子。（3）结果：MAFLD患者与对照组的脂联素和内脂素水平无显著差异。在内脂素与平均颈动脉内膜中层厚度相关（P值=0.047），而在对照组中脂联素与左心室射血分数（LVEF）相关（P值=0.039）以及E/A比值相关（P值=0.002）。在单因素分析中，脂联素与E/A比值之间的关联在95%置信区间有统计学意义（0.0049 - 0.1331，P值=0.035），但在多因素分析后失去统计学意义。尽管在单因素分析中LVEF与脂联素不相关，但在多因素分析后观察到有统计学意义的值（95%置信区间（-1.83 - -0.22，P值=0.015））。（4）结论：未发现MAFLD患者与对照组血清脂联素和内脂素水平有显著差异。有趣的是，尽管在单因素分析中脂联素水平与LVEF不相关，但在多因素分析后观察到显著的负相关。
